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Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts
Authors
Hattori Atsuhiko
Ikegame Mika
+7 more
Moriyama Shunsuke
Sakamoto Tatsuya
Suzuki Nobuo
Takagi Chiyo
Takahashi Akiyoshi
Takahashi Hideya
Yamamoto Toshio
Publication date
1 July 2008
Publisher
'Zoological Society of Japan'
Doi
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Abstract
In teleosts, prolactin is involved in calcium regulation, but its role in scale/bone metabolism Is unclear. Using the in-vitro system with goldfish scales developed recently, we explored the effects of teleost prolactin, growth hormone, and somatolactin on osteoclasts and osteoblasts. Addition of prolactin at concentrations of 0.01-100 ng/ml reduced osteoclastic activity, partly via osteoclast apoptosis, after 6-18 h incubation. Conversely, growth hormone and somatolactin at a concentration of 100 ng/ml increased osteoclastic activity after 18 h incubation, indicating the specificity of the inhibitory effect of prolactin on osteoclastic activity. On the other hand, these three hormones promoted osteoblastic activity at concentrations of 10-100 ng/ml. The results from this study are the first demonstration of direct effects of prolactin on scale/bone metabolism and osteoclastic activity in a teleost. © 2008 Zoological Society of Japan
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Last time updated on 06/05/2019