金沢大学大学院自然科学研究科分子作用学金沢大学薬学

Nambara Toshio

Shimada Kazutake

Chemical and Pharmaceutical Bulletin

Kanazawa University Repository for Academic Resources

Isolation and Characterization of a New Typeof Bufotoxin from the Skin of Bufo americanus著者 Shimada Kazutake, Nambara Toshiojournal orpublication titleChemical & pharmaceutical bulletinvolume 28number 5page range 1559-1562year 1980-05-25URL http://hdl.handle.net/2297/7067－．－－--=､--.----.ざ己一二-－．－－騨蕊堂､干二＝霧■ |， 1561 P可L｣ 嬢蕊蕊l蕊SynthesisofMarinobufagin3-Suberoyl-D-glutamineEster(V)－D-Glutamine(１０ｍｇ)ｉｎＨ２０(１ｍl)ｗａｓ Ｃ，６２．４３；Ｈ，７．７９；Ｎ，3.94．Ｆｏｕｎｄ：Ｃ，62.10；Ｈ，７．６９；Ｎ，３．７４． ＴＬＣComparisonoflVwithMarinobufagin3-Suberoyl-D-glutamicAcid,‐L-glutamicAcidand-L-iso-glutamineEsters-D-G1utamicacid,L-glutamicacidorL-isoglutaｍｉｎｅ(２ｍｇ)ｉｎＨ２０(0.5-1ｍl)wasadded toasolutionofmarinobufagin3-hemisuberateカーnitrophenylester（111）（３ｍｇ)inpyridine（２ｍl)ａｎｄtheresultmgsolutionwasallowedtostandatroomtemperatureforl2hr･Thereactionmixturewasevaporateｄ ｄｏｗｎｕｎｄｅｒａｎＮ２ｇａｓｓｔｒｅａｍａｎｄｔｈｅｒesiduewassubjectedtoTLCusingCHC13F-MeOH-H20(80:２０:2.5） asadevelopingsolvent・EachconjugateshowedaspotatZV0.10,clearlydistinguishablefromthatoflV(町0.20)．illilllI 

Isolation and Characterization of a New Type of Bufotoxin from the Skin of Bufo americanus

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Isolation and Characterization of a New Type of Bufotoxin from the Skin of Bufo americanus

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