Knudsen, C.

Mosekilde, Erik

O'Meara, N.M.

Polonsky, K.S.

Sturis, J.

Thomsen, J.S.

Van Cauter, E.

We present a detailed numerical investigation of the phase-locking regions in a forced model of slow oscillations in human insulin secretion and blood glucose concentration. The bifurcation structures of period 2pi and 4pi tongues are mapped out and found to be qualitatively identical to those of several other periodically forced self-oscillatory systems operating acrocss a Hopf-bifurcation point. The numerical analyses are supplemented by clinical experiments

Phase-locking regions in a forced model of slow insulin and glucose oscillations

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