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The effect of miRNA mimic hsa-miR-7704 on in-vitro replication of herpes simplex virus type 1
Authors
A. Mirzaei
S. Moghim
+4 more
B. Nasr-Esfahani
B. Sadegh-Ehdaei
M. Shabani
M.R. Sharifi
Publication date
1 January 2018
Publisher
Isfahan University of Medical Sciences(IUMS)
Abstract
Background: Herpes simplex virus type 1 (HSV-1) infections are of the most common diseases in human population. HSV-1 can cause subclinical to severe diseases, especially in immunocompromised patients. There are few anti-herpes drugs for treatment of HSV-1 infection. Acyclovir is one of the most important drugs. The extensive use of this drug has led to the development of resistant strains. Therefore, development of new anti-herpes drugs with different mechanisms is noticeable. This study aimed to use microRNAs as a novel method for inhibiting HSV-1 infection. Methods: Synthesized miRNA mimics hsa-miR-7704 (miR-SX1) were transfected into Hela cells, and then infected with HSV-1. Cellular morphological changes were observed 24 hours post-infection by inverted microscope, and photographed. Viral titers were measured using 50 tissue culture infective dose (TCID 50 ) method. Findings: miR-SX-1-transfected cells produced low-titer HSV-1, without affecting cell viability. Conclusion: The data suggest that miR-SX1 inhibits HSV-1 replication, and may provide an alternative mechanism to prevent HSV-1 infection. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved
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oai:eprints.kaums.ac.ir:3810
Last time updated on 05/05/2019