This communication presents the Project aimed to create, implement and develop an institutional repository, called REPISALUD, within the context of a Public Biomedical Research Organization: the Instituto de Salud Carlos III (ISCIII) and its Foundations, the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro Nacional de Investigaciones Oncológicas (CNIO). It describes the main aspects in the implementation of the repository, suggesting future actions and developments that will lead to the consolidation of REPISALUD. The creation of REPISALUD is part of an institutional project to promote Open Access, which began after the signing by the directors of the three institutions of the Berlin Declaration in 2016. The Project is being led by the libraries or documentation units of the institutions involved. This Project is based on the need to create a unified Open Access platform for the scientific and technical publications of the ISCIII and its foundations. REPISALUD offers the advantage of uniting in a single repository the scientific production of the three institutions and, therefore, having a single Access point for all the collections. The communication describes the procedures to be followed and the most relevant aspects of the development in relation to the definition of the repository, choice of the software, the planning and implementation of the project, as well as its maincharacteristics: open content policy, interoperability and service to the researcher, etc., thus creating a fundamental tool for the preservation, dissemination and organization of the scientific productivity generated within the participating institutions. In the design of the repository, special attention has been paid to the inclusion of funding data, theen richment of information on the authors of the three institutions, through links to their identifiers (ORCID, ResearcherID and Scopus Author ID), and the policy of inclusion of all types of scientific productivity, including, in addition to the articles and contributions to conferences, training material, institutional, dissemination, research data, etc., so that the repository can become a true reflection of all scientific activity of the three institutions