Hasani Sadi, Shima

Simorgh Research Repository

     داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ و ﺧﺪﻣﺎت ﺑﻬﺪاﺷﺘﻲ درﻣﺎﻧﻲ ﻛﺮﻣﺎن  داﻧﺸﻜﺪه داروﺳﺎزي وﻋﻠﻮم داروﻳﻲ   ﺎﻳﺎن ﻧﺎﻣﻪ دﻛﺘﺮاي ﻋﻤﻮﻣﻲ داروﺳﺎزيﭘ ﻋﻨﻮان: يﻋﺼﺎره درد ﺿﺪ ژل ﺷﻴﻤﻴﺎﻳﻲ ﻓﻴﺰﻳﻜﻮ ﺧﺼﻮﺻﻴﺎت ﺑﺮرﺳﻲ و ﻓﺮﻣﻮﻻﺳﻴﻮن  ﺷﻨﺒﻠﻴﻠﻪ يداﻧﻪ ي ﺷﺪه اﺳﺘﺎﻧﺪارد ﻫﻴﺪرواﻟﻜﻠﻲ    :ﺗﻮﺳﻂ  ﺳﻌﺪي ﺣﺴﻨﻲﺷﻴﻤﺎ   : اﺳﺎﺗﻴﺪ راﻫﻨﻤﺎ  دﻛﺘﺮ ﻣﻬﺪي اﻧﺼﺎري دﻛﺘﺮ ﻓﺮﻳﺒﺎ ﺷﺮﻳﻔﻲ ﻓﺮ  1601:ﻧﺎﻣﻪﺷﻤﺎره ﭘﺎﻳﺎن                                                               7931زﻣﺴﺘﺎن     Kerman University of Medical Sciences Faculty of Pharmacy  Pharm. D Thesis    Title: Formulation and physicochemical properties of analgesic gel containing fenugreek seeds (Trigonella foenum graceum L.) standard hydroalcoholic extract    By: Shima Hasani Sadi   Supervisors: Dr. Mahdi Ansari Dr. Fariba Sharififar   December 2013                                          Thesis No.: 1061 I     ﺧﻼﺻﻪ ﻓﺎرﺳﻲ                                  ﺧﻼﺻﻪ ﻓﺎرﺳﻲﺗﻮاﻧﺪ ﻣﻮﺟﺐ ﻣﺨﺘﻞ ﺷﺪن ﻓﺮآﻳﻨﺪ ﻋﺎدي زﻧﺪﮔﻲ ﻓﺮد د اﺣﺴﺎس آزار دﻫﻨﺪه اي اﺳﺖ ﻛﻪ ﻣﻲدر ﻣﻘﺪﻣﻪ:ﺷﻮد. ﺑﻪ ﻫﻤﻴﻦ دﻟﻴﻞ داروﻫﺎي ﺿﺪ درد از ﺟﻤﻠﻪ اﭘﻴﻮﻳﻴﺪﻫﺎ و ﺿﺪ درد ﻫﺎي ﻏﻴﺮ اﺳﺘﺮوﻳﻴﺪي از ﭘﺮﻣﺼﺮف ژل ،  ﻣﺎﻧﻨﺪ اراﺋﻪ ي ﻳﻚ ﻓﺮﻣﻮﻻﺳﻴﻮن ﻣﻮﺿﻌﻲ ﻛﻢ ﻋﺎرﺿﻪ ﺑﺎ اﺛﺮ ﺿﺪ درد ﻣﻨﺎﺳﺐ ﺗﺮﻳﻦ داروﻫﺎ ﻫﺴﺘﻨﺪ.ﺷﻨﺒﻠﻴﻠﻪ از ﮔﻴﺎﻫﺎﻧﻲ اﺳﺖ ﻛﻪ اﺛﺮات ﺿﺪ درد آن در ﻣﻨﺎﺑﻊ ﻣﺨﺘﻠﻒ  .رﺳﺪﻣﻮﺿﻌﻲ ﺿﺮوري ﺑﻪ ﻧﻈﺮ ﻣﻲﻴﺰﻳﻜﻮﺷﻴﻤﻴﺎﻳﻲ ژل ﻣﻮﺿﻌﻲ از اراﺋﻪ و ﺑﺮرﺳﻲ ﺧﺼﻮﺻﻴﺎت ﻓ ،ﮔﺰارش ﺷﺪه اﺳﺖ. ﻫﺪف از اﻳﻦ ﺗﺤﻘﻴﻖ  .ﺑﺎﺷﺪﻣﻲ ﻴﺪرواﻟﻜﻠﻲ  داﻧﻪ ﺷﻨﺒﻠﻴﻠﻪه ﻫﻋﺼﺎرﺗﻬﻴﻪ ﮔﺮدﻳﺪ. و ﺑﺮاي ﺗﻬﻴﻪ ي  %08ﻋﺼﺎره داﻧﻪ ﺷﻨﺒﻠﻴﻠﻪ ﺑﺎ روش ﻣﺎﺳﺮاﺳﻴﻮن ﮔﺮم ﺑﺎ اﺗﺎﻧﻮل روش ﻛﺎر : ﭘﻠﻴﻤﺮ و ﻣﺎده ي ژل ﻛﻨﻨﺪه و ﺳﺎﻳﺮ ﻣﻮاد ﺑﻪ ﻫﻤﺮاه ﻋﺼﺎره در ﺣﻼل ﺣﻞ ﺷﺪه و از اﺧﺘﻼط و ژل، ﺷﻜﻞ ﻇﺎﻫﺮي  ﻪ ﺧﺼﻮﺻﻴﺎﺗﻲ ﻫﻤﭽﻮن ﭘﺎﻳﺪاري،ﻫﻤﻮژﻧﺎﻳﺰ ﻛﺮدن ﻣﻮاد ﺑﺎ ﻫﻢ ژل ﻳﻜﻨﻮاﺧﺘﻲ ﺣﺎﺻﻞ ﺷﺪ ﻛ  ﻣﻮرد ﺑﺮرﺳﻲ  ﻗﺮار ﮔﺮﻓﺖ.و ﺳﻴﻨﺮزﻳﺲ ﻣﻮﺿﻌﻲ ﻧﺘﺎﻳﺞ ﺑﻪ دﺳﺖ آﻣﺪه ﻧﺸﺎن داد ﻛﻪ ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﻣﺘﺪ ﺑﻪ ﻛﺎر رﻓﺘﻪ در اﻳﻦ ﻓﺮﻣﻮﻻﺳﻴﻮن، ژل ﻧﺘﺎﻳﺞ: ي ي ﺷﺶ ﻣﺎﻫﻪ ﻋﺼﺎرهدر ﻃﻮل دوره ،آﻳﺪ. ﺗﺴﺖ ﭘﺎﻳﺪاري ﻧﺸﺎن دادﻳﻜﻨﻮاﺧﺖ و ﺷﻔﺎﻓﻲ ﺑﻪ دﺳﺖ ﻣﻲاي دو ﺗﻮان ﻋﻤﺮ ﻗﻔﺴﻪو ﻣﻲ ﻗﺎﺑﻞ ﻗﺒﻮﻟﻲ ﺑﺮﺧﻮردار ﺑﻮدهاز ﭘﺎﻳﺪاري  ﺟﻮد در ﻓﺮﻣﻮﻻﺳﻴﻮنﺷﻨﺒﻠﻴﻠﻪ ي ﻣﻮ  ﺑﺮاي ژل ﻣﻮﺿﻌﻲ ﻋﺼﺎره اﻟﻜﻠﻲ ﺷﻨﺒﻠﻴﻠﻪ در ﻧﻈﺮ ﮔﺮﻓﺖ. را ﺳﺎلي ي ﻫﻴﺪرواﻟﻜﻠﻲ داﻧﻪﻋﺼﺎرهﺗﺤﻘﻴﻘﺎﺗﻲ ﺗﻮاﻧﺴﺘﻪ اﺳﺖ ژل ﻣﻮﺿﻌﻲ  اﻳﻦ ﭘﺮوژهﺑﺤﺚ و ﻧﺘﻴﺠﻪ ﮔﻴﺮي:   ﺎﻳﻲ ﻗﺎﺑﻞ ﻗﺒﻮل ﻋﺮﺿﻪ ﻧﻤﺎﻳﺪ.ﺷﻨﺒﻠﻴﻠﻪ را ﺑﺎ ﺧﻮاص ﻇﺎﻫﺮي و ﭘﺎﻳﺪاري ﺷﻴﻤﻴ، ژل ﻣﻮﺿﻌﻲ، ﻓﺮﻣﻮﻻﺳﻴﻮنﺷﻨﻴﻠﻴﻠﻪ، ﻋﺼﺎره ﻫﻴﺪرواﻟﻜﻠﻲﻟﻐﺎت ﻛﻠﻴﺪي:                                ﻲﺳرﺎﻓ ﻪﺻﻼﺧ     2  English Abstract   Introduction: Pain is a distressing feeling which may cause disturbance in human normal life. For this reason, analgesics such as opioids and nonsteroidal painkillers are the most commonly used drugs. It seems immediate to represent a proper low-hazardous topical formulation with painkilling effects, such as topical gels. Fenugreek is a plant that its painkilling effects have been reported in many resources. This research aimed to study and present the physicochemical properties of topical gel, made from hydroalcoholic extract of fenugreek seeds.  Methods: Fenugreek seeds extract is prepared by hot maceration method using 80% ethanol, and for preparation of the gel, the polymer and jellifier with other ingredients in conjunction with the extract were dissolved in the solvent. After mixing and homogenization of materials, a uniform gel obtained, and then properties like stability, appearance, and syneresis had been studied. Results: The results show that, a uniform and transparent gel will be obtained by the applied method in this formulation. Stability test in six month interval reveals that the existing fenugreek extract in the formulation had a tolerable stability, and a two years shelf life for the hydroalcoholic extract of fenugreek could be estimated. Discussion and conclusion: This research project was able to present the topical gel of fenugreek seeds hydroalcoholic extract along with extensive properties and acceptable chemical stability. Keywords: Fenugreek, Topical Gel, Alcoholic Extract, Formulation   

فرمولاسیون و بررسی خصوصیات فیزیکو شیمیایی ژل ضد درد عصارهی هیدروالکلی استاندارد شده ی دانهی شنبلیله

http://eprints.kmu.ac.ir/30861/1/7054.pdf

فرمولاسیون و بررسی خصوصیات فیزیکو شیمیایی ژل ضد درد عصارهی هیدروالکلی استاندارد شده ی دانهی شنبلیله

Abstract

Similar works

Full text

Available Versions

Simorgh Research Repository