Scabies is an infectious skin disease caused by mite Sarcoptes scabiei var. hominis. Scabies transmission can occur directly and indirectly. Approximately more than 300 million people in worldwide are affected by scabies. This disease is commonly found in densely populated environments, such as Islamic boarding schools. The lack of healthy hygiene behavior and low education level are the supporting factors for the occurrence of scabies. To find out the relationship between education level and hygiene behavior with the incidence of scabies. This study used a cross-sectional study design and was conducted at the Nurul Ummah Islamic Boarding School in Yogyakarta. The research subjects were 80 people taken by cluster sampling technique. Data obtained through physical examination, interviews, and distribution of questionnaires to respondents. The data obtained was processed and analyzed using the statistical method chi square and analysis with logistic regression test. The results of the chi square test showed that there was a significant relationship between the level of education and the incidence of scabies (p=0.001). The relationship between healthy hygiene behavior and the incidence of scabies showed significant results (p=0.002). The results of multivariate analysis that obtained a more significant relationship with the level of education (p = 0.004) compared to healthy healthy life (p = 0.017) with the incidence of scabies. There is a significant relationship between education level and hygiene behavior with the incidence of scabies
