Efek Ekstrak Rimpang Temu Putih Terhadap Kadar Kreatinin dan Kadar Ureum Pada Tikus Jantan Galur Wistar (Rattus novergicus) Model Gagal Ginjal yang diinduksi Gentamisin
White turmeric’s rhizome (Curcuma zedaoria) has several ingredients, including curcumin, flavonoids, essential oils. The content of curcumin at the extract White turmeric’s rhizome (Curcuma zedoaria) has a function as a protector of the kidneys so that it can reduce blood creatinine levels and blood urea levels. The purpose of this study was to determine the effect extract of White turmeric’s rhizome (Curcuma zedoaria) on blood creatinine levels and blood urea levels of male wistar (Rattus novergicus) strain of rats induced by gentamicin. This study uses a laboratory experimental research design with the design of pre and post test with controlled group design. The research subjects used were extract White turmeric’s rhizome (Curcuma zedoaria) with a dose of 20mg /200gBW, 40mg /200gBW, and 80mg/200gBW. A total of 25 male Wistar (Rattus novergicus) strain rats were used as research objects. Test animals were divided into 5 groups, namely the normal group (aquadest), gentamicin group (kidney damage), treatment group I (dose 20mg / 200gBW), treatment group II (40mg / 200gBW dose), treatment group III (dose 80mg / 200gBW) . Data were analyzed by SPSS version 25. Oneway Anova test on creatinine levels and urea levels were obtained p = 0.001 and p = 0.003 (p <0.05) respectively which means that were differences in effects on creatinine levels and urea levels between groups. It was continued by Post-Hoc analysis with LSD Test between groups of creatinine levels and urea levels there were significant differences (p <0.05). The conclusions of this study are the effects of the administration of extract White turmeric’s rhizome (Curcuma zedaoria) at doses of 20mg/200gBW, 40mg/200gBW, and 80mg/200gBW on blood creatinine levels and blood urea levels in Wistar male rats (Rattus novergicus) that induced by gentamicin
