Pharyngitis is an inflammation on the pharyngeal wall. Pharyngitis can be caused by bacteria and viruses. Today many people are using herbs as health therapy. One of the herbs that is often used is ant-nest plants (Myrmecodia Tuberosa) originating from Papua, this plant is proven empirically effective to cure diseases and contain active compounds flavonoids that have anti-inflammatory effects. This research was conducted to find out whether there is influence of 10% ethanolic extract of ant-nest plant extract (Myrmecodia tuberosa) to decrease levels of Tumor Necrosis Factor-Alpha in patient with acute pharyngitis.
This study uses pretest-posttest group only design. Objects used in the study were levels of Tumor Necrosis Factor-Alpha saliva pretest and posttest obtained from 16 patients with acute pharyngitis. Treatment had been done by giving gargle solution used twice a day for two days, then measured levels of tumor necrosis factor-Alpha with Enzyme-linked Immunosorbent Assay method using ELISA Kit and ELISA Reader to read the results of Tumor Necrosis Factor-Alpha saliva pretest and posttest. Data analysis uses Paired T-Test parametric test.
The results showed that the concentration of 10% ethanol extract of ant-nest plants (Myrmecodia tuberosa) could influence the decrease of Tumor Necrosis Factor-Alpha level in acute pharyngitis patient. The average of Necrosis Factor-Alpha pretest (0.118) and posttest (0,109) . Based on the results of Paired T-Test parameters test obtained value p = 0,002 (p <0,05). Based on this research, it can be concluded that ethanol gargle solution (Myrmecodia tuberosa) has an effect on decreasing levels of Tumor Necrosis Factor-Alpha in pretest and posttest saliva group as indicated by the different values of Tumor Necrosis Factor-Alpha levels between the two groups
