Background: Aim of this study was to evaluate peri-procedural incidence of new diffusion-weighted-magneticresonance-
imaging (DWMRI) brain lesions in CAS patients treated by carotid mesh stent (CGuard™) or
closed-cell stent (Wallstent™).
Methods: Consecutive patients with asymptomatic carotid stenosis ≥ 70% were submitted to preoperative DWMRI
scan, to exclude the presence of preoperative silent cerebral lesions. Patients were randomized to CGuard
orWallstent. DWMRI was performed immediately after the intervention and at 72-hour postoperatively. Moreover,
pre and postoperative Mini-Mental-State-Examination Test (MMSE) and aMontreal-Cognitive-Assessment
(MoCA) test were conducted, and S100β and NSE neurobiomarkers were measured at 5-time points (preoperatively,
2, 12, 24, and 48 h postoperatively).
Results: From January 2015 to October 2016, sixty-one consecutive eligible patients were submitted to preoperative
DWMRI scan. Three patients were excluded because of preoperative silent cerebral lesions. In 29 CGuard
patients, 1 developed a minor stroke and 8 silent newlesionswere observed in the 72 h-DWMRI (31%): 4 lesions
were ipsilateral, and 4 lesions were contra or bilateral. In 29 Wallstent patients, 7 clinically-silent new lesions
were found in the 72 h-DWMRI (24.1%; p = 0.38). In 4 cases lesions were ipsilateral and in 3 cases contra or
bilateral. S100B values doubled at 48 h in 24 patients, and among them 12 presented new DWMRI lesions.
48-h S100B increase was significantly related to 72-h DWMRI lesions (p= 0.012).
Conclusions: In our experience both stents showed an acceptable rate of subclinical neurological events with no
significant differences at 72-hour DWMRI between groups. Bilateral/contralateral lesions suggest that
periprocedural neurological damage may have extra-carotid sources
