Disseldorp, EMJ Emiel  van

Lopata, RGP Richard

Petterson, NJ Niels

Sambeek, MRHM  van

Vosse, FN Frans  van de

van Disseldorp, E.M.J.

Petterson, N.J.

van de Vosse, F.N.

van Sambeek, Marc R.H.M.

Lopata, R.G.P.

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Abdominal aortic aneurysms: wall stress analysis and mechanical characterization using 4D ultrasound

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Abdominal aortic aneurysms:wall stress analysis and mechanical characterization using 4D ultrasound

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 Abdominal aortic aneurysmsCitation for published version (APA):van Disseldorp, E. M. J., Petterson, N. J., van de Vosse, F. N., van Sambeek, M. R. H. M., & Lopata, R. G. P.(2016). Abdominal aortic aneurysms: wall stress analysis and mechanical characterization using 4D ultrasound.Poster session presented at Mate Poster Award 2016 : 21st Annual Poster Contest.Document status and date:Published: 01/01/2016Please check the document version of this publication:• A submitted manuscript is the version of the article upon submission and before peer-review. There can beimportant differences between the submitted version and the official published version of record. Peopleinterested in the research are advised to contact the author for the final version of the publication, or visit theDOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and pagenumbers.Link to publicationGeneral rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license above, pleasefollow below link for the End User Agreement:www.tue.nl/taverneTake down policyIf you believe that this document breaches copyright please contact us at:openaccess@tue.nlproviding details and we will investigate your claim.Download date: 15. Jul. 2024IntroductionAn abdominal aortic aneurysm (AAA) is a hazardous,asymptomatic condition that can lead to a fatalhaemorrhage when ruptured (Figure 1).The problem: Rupture risk assessment is nowadays basedon the maximum diameter: an inadequate criteria. A morepatient-specific approach is needed.The aim: Perform wall stress analysis using 4D (3D+time)ultrasound (US), and characterize the mechanical behaviourof the AAA wall.MethodsForty patients (60-85 years) were included and gave theirinformed consent. 3D ultrasound imaging (Philips iU22,X6-1 matrix probe) was performed, after which the 3Ddisplacement field was calculated using speckle tracking.For 7 out of 40 patients also CT data were available.Finite Element AnalysisThe data were manually segmented and the corresponding3D geometry was converted into a mesh. An incompressibleNeo-Hookean material model was applied to compute thewall displacements. The patient-specific shear modulus wasderived by calibrating the estimated FEA wall displacementsto the measured US wall motion.Abdominal Aortic AneurysmsWall stress analysis and mechanical characterization using 4D ultrasoundE.M.J. van Disseldorp1,2, N.J. Petterson1, F.N. van de Vosse1, M.R.H.M. van Sambeek2, R.G.P. Lopata11Cardiovascular Biomechanics, Dept. of Biomedical Engineering, Eindhoven University of Technology2Dept. of Vascular Surgery, Catharina Hospital Eindhoven/ Department of Biomedical EngineeringResultsPatient-specific US-based wall stresses were in agreementwith CT and are visualized in the US data in Figure 4.The 99th percentile wall stress was calculated and shownas function of the AAA diameter. This revealed the presenceof small AAAs with high peak wall stresses and large AAAswith relatively low stresses (Figure 5).Patient-specific material representative (Ginc) was derived,and divided in three groups. It showed a significant increasedarterial stiffness with respect to the AAA diameter (Figure 5).DiscussionThis study shows that 4D US-based wall stress analysis ofAAAs has the potential to aid in AAA rupture risk assessmentby identifying patients at risk, and to monitor patients overtime by detecting changes in wall stress and materialproperties.Ongoing work includes a novel automatic segmentation andregistration algorithm to include a large volume of patients(>300) and to perform and long-term follow-up.Figure 1: Example of a normal aorta and an abdominal aortic aneurysm (AAA).Figure 2: CT image of an AAA (left), with the typical field-of-view of ultrasound (whitedashed line) and the corresponding 3D ultrasound volumetric image (right).Figure 3: In-vivo measured wall displacements were used to calibrate the Finite element model.kPaFigure 4: Longitudinal cross-sections of three typical AAA geometries with the correspondingVon-Mises wall stress distribution visualized.Figure 5: The 99th percentile wall stress as function of the AAA diameter (left). The patient-specific material property (Ginc) is shown for a small, medium, and large AAA diameter group.The large AAAs revealed an increased elastic modulus.Figure 6: Proximal and distal 3D US volume (left) with merged 3D US volume (right).

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Abdominal aortic aneurysms:wall stress analysis and mechanical characterization using 4D ultrasound

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