In order to research the regular pattern of the vortex within the oil-gas multiphase pump with the gas volume fraction changes, the standard K-epsilon turbulence model is selected, the gas-liquid two-phase flow field within the multiphase pump is calculated by the CFD software under the different gas volume fraction, the regular pattern of the vortex motion within the multiphase pump is analyzed under the different gas volume fraction. The results show that, from the impeller hub to the rim, the vortex in the guide vane is gradually become smaller, the vortex within the impeller is gradually obvious, and with the increase of the gas volume fraction, the flow separation, the backflow and the vortex phenomenon within the impeller and the guide vane are gradually increased. It is also found that the flow separation has a greater influence on the turbulent dissipation within the whole flow field, that is, the more serious the area of off flow, the greater the energy loss. The results provide an important theoretical basis for the optimal design of the structure of oil-gas multiphase pump