A Ilyas

A Radenovic

AS Prabhu

B Cressiot

BJ Polk

BM Venkatesan

C Danelon

CC Harrell

Chuanrong Hou

D Stoddart

G Jagerszki

Jingjing Yu

JK Rosenstein

JL Kong

KJ Freedman

L Liu

Lei Wang

LZ Wu

M Ali

M Wanunu

O Braha

OJ Lee JH

P Chen

QT Zhao

Quanjun Liu

RE Gyurcsanyi

RMM Smeets

Rui Jiang

S Cheley

Shengwei Tan

SM Iqbal

V Mussi

W Asghar

W-J Lan

Y Zhang

Yanping Li

YR Kim

Nanoscale Research Letters

Abstract
          Nanopores have been proven to be novel and versatile single-molecule sensors for individual unlabeled biopolymer detection and characterization. In the present study, a relatively large silicon nitride (Si3N4) nanopore with a diameter of approximately 60 nm was fabricated successfully using a focused Ga ion beam (FIB). We demonstrated a simple ex situ silanization procedure to control the size and functionality of solid-state nanopores. The presented results show that by varying the silanization time, it is possible to adjust the efficiency of probe molecule attachment, thus shrinking the pore to the chosen size, while introducing selective sensing probes. The functionalization of nanopores was verified by analysis of field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDS), and electrical measurements. Based on this study, we envision that the functionalized silicon nitride nanopores with the DNA probe might provide a biosensing platform for the detection and discrimination of a short single-stranded DNA oligomer of unknown sequences in the future.</jats:p

Crossref

DNA-functionalized silicon nitride nanopores for sequence-specific recognition of DNA biosensor

https://nanoscalereslett.springeropen.com/track/pdf/10.1186/s11671-015-0909-0?site=nanoscalereslett.springeropen.com

DNA-functionalized silicon nitride nanopores for sequence-specific recognition of DNA biosensor

Abstract

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