A Diaz

A Ron

AC Binks

EJ Ley

FG Chen

FL Ferreira

G Ansari

G Zuanetti

GG Stanford

H Hamishehkar

JL Vincent

JP Nolan

K Fox

K Werdan

K Zorn-Pauly

KK Marcoux

L Mcilvoy

L Wilhelmsen

M Böhm

M Shiehmorteza

MT Cooney

MU Rehman

P Lechat

R Abrishami

R Levy

RB Becker

S Kishner

S Mousavi

SM Lobo

UE Heidland

WA Knaus

DARU : Journal of Pharmaceutical Sciences

Abstract
          
            Background
            The importance of resting heart rate as a prognostic factor was described in several studies. An elevated heart rate is an independent risk factor for adverse cardiovascular events and total mortality in patients with coronary artery disease, chronic heart failure, and the general population. Also heart rate is elevated in the Multi Organ Dysfunction Syndrome (MODS) and the mortality due to MODS is highly correlated with inadequate sinus tachycardia.
            To evaluate the value of resting heart rate in predicting mortality in patients with traumatic brain injury along scoring systems like Acute Physiology and Chronic Health Evaluation(APACHE II), Sequential Organ Failure Assessment (SOFA) and Glasgow Coma Score (GCS).
          
          
            Method
            By analyzing data which was collected from an open labeled randomized clinical trial that compared the different means of osmotherapy (mannitol vs bolus or infusion hypertonic saline), heart rate, GCS, APACHE II and SOFA score were measured at baseline and daily for 7 days up to 60 days and the relationship between elevated heart rate and mortality during the first 7 days and 60th day were assessed.
          
          
            Results
            After adjustments for confounding factors, although there was no difference in mean heart rate between either groups of alive and expired patients, however, we have found a relative correlation between 60th day mortality rate and resting heart rate (P=0.07).
          
          
            Conclusion
            Heart rate can be a prognostic factor for estimating mortality rate in brain injury patients along with APACHE II and SOFA scores in patients with brain injury.
          </jats:sec

Mahsa Hasanpour Mir

Fardin Yousefshahi

Mohammad Abdollahi

Arezoo Ahmadi

Atabak Nadjafi

Mojtaba Mojtahedzadeh

Crossref

DARU Journal of Pharmaceutical Sciences

The predictive value of resting heart rate following osmotherapy in brain injury: back to basics

The predictive value of resting heart rate following osmotherapy in brain injury: back to basics

Abstract

Similar works

Full text

Available Versions

Crossref