A method for optimizing rail profiles to improve vehicle running stability in switch panel of high-speed railway turnouts is proposed in this paper. The stock rail profiles are optimized to decrease the rolling radii difference (RRD). Such characteristics are defined through given rail profiles, and the target rolling radii difference is defined as a function of lateral displacements of wheel set. The improved sequential quadratic programming (SQP) method is used to generate a sequence of improving profiles leading to the optimum one. The wheel-rail contact geometry and train-turnout dynamic interaction of the optimized profiles and those of nominal profiles are calculated for comparison. Without lateral displacement of wheel set, the maximum RRD in relation to a nominal profile will be kept within 0.5 mm–1 mm, while that in relation to an optimized profile will be kept within 0.3 mm–0.5 mm. For the facing and trailing move of vehicle passing the switch panel in the through route, the lateral wheel-rail contact force is decreased by 34.0% and 29.9%, respectively, the lateral acceleration of car body is decreased by 41.9% and 40.7%, respectively, and the optimized profile will not greatly influence the vertical wheel-rail contact force. The proposed method works efficiently and the results prove to be quite reasonable
