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Colloidal particle motion as a diagnostic of DNA conformational transitions

Abstract

Tethered particle motion is an experimental technique to monitor conformational changes in single molecules of DNA in real time, by observing the position fluctuations of a micrometer-size particle attached to the DNA. This article reviews some recent work on theoretical problems inherent in the interpretation of TPM experiments, both in equilibrium and dynamical aspects.Comment: 19pp. Accepted for publication in Curr Op Colloid Interf Scienc

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