Annegret Hüttel

Christoph Benk

Claudia Otto

Daniela Huzly

DR Cincotta

G Poggensee

Gian Kayser

JS Nguyen-Van-Tam

JW Delaney

JY Heo

LA Danziger-Isakov

Lars Kemna

LP Hariri

M Panning

Martin Werner

MB Beasley

MP Girard

S Bhatti

SG Spiro

Siegbert Rieg

SM Lee

Till Ploenes

X Wang

BMC Pulmonary Medicine

Abstract
          
            Background
            Immunocompromised patients, particularly after lung transplantation, are at high risk to develop atypical forms of pulmonary infections including influenza A/H1N1. Acute Fibrinous and Organizing Pneumonia (AFOP) is a special histological pattern in acute respiratory failure with high mortality.
          
          
            Case presentation
            We describe a 66-year-old woman with double lung transplantation in August 2009 due to end stage pulmonary fibrosis. After prolonged weaning and subsequent promising course, she developed atypical pneumonia with diffuse pulmonary infiltrates in both lungs in January 2010. Infection with influenza A/H1N1 virus was verified. The patient rapidly suffered from respiratory insufficiency and died eight days after this diagnosis. The post-mortem revealed especially in the lower parts of the lungs the classical histological pattern of pure AFOP. Molecular analyses of lung tissue were positive for influenza A/H1N1.
          
          
            Conclusion
            To our knowledge we present the first case of AFOP triggered by viral infection, here proven to be influenza virus A/H1N1. Thus, also in the setting of viral infection the highly deadly differential diagnosis of AFOP must be considered.
          </jats:sec

Crossref

Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation

https://bmcpulmmed.biomedcentral.com/track/pdf/10.1186/1471-2466-13-30?site=bmcpulmmed.biomedcentral.com

Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation

Abstract

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