Aromatic chlorination of toluene and of anisole using clay-supported iron(III) chloride and m-chloroperbenzoic Acid - A biomimetic approach

Abstract

n the presence of meta-chloroperbenzoic acid, clay-supported ferric chloride is an efficient aromatic chlorinating agent for toluene and anisole. Influence of various experimental factors such as the nature of the solvent, the peracid or the metallic cation were investigated. These reactions represent a laboratory equivalent to biological halogenations through oxidation of halide ions by peroxidases in the presence of hydrogen peroxide