Examination of the efficacy of various feed additives on the pathomorphological changes in broilers treated with T-2 toxin

Abstract

A 21-day-long experiment was performed on 160 one-day-old 'Ross' broiler chicks. This research was done with the aim of investigating pathomorphological changes in broilers exposed to a relatively small amount of T-2 toxin (2 ppm) and the possibility of prevention and/or alleviating adverse effects of T-2 toxin using various feed additives. Pathohistological examination showed negative consequences of T-2 toxin in all examined organs as degenerative changes developed in small intestine mucosa, enterocites and hepatocites necroses, as well as lymphocites depletion in bursa of Fabricius. Disparately from inorganic (Minazel-plus, Mz) and organic (Mycosorb, Ms) adsorbents, which did not provoke protective effects, in liver, small intestine and bursa of Fabricius of broilers who were given feed with T-2 toxin and mixed adsorbent (Mycofix-plus, Mf), mostly preserved structure of these organs could be noted.Eksperiment je izveden na 160 jednodnevnih brojlerskih pilića provenijencije 'Ross', u trajanju od 21 dan. Istraživanja su bila usmerena na omogućavanje detaljnijeg uvida u patomorfološke promene kod brojlera izloženih dejstvu relativno niskih doza T-2 toksina (2 ppm), kao i mogućnosti prevencije ili ublažavanja štetnih efekata korišćenjem različitih adsorbenata. Patohistološkom analizom isečaka tankog creva, jetre i Fabricijeve burze, uočeni su efekti T-2 toksina u svim ispitivanim organima, u vidu degenerativnih promena na sluznici tankog creva, nekroze enterocita i hepatocita, kao i deplecije limfocita u Fabricijevoj burzi. Za razliku od neorganskog (Minazel-plus, Mz) i organskog (Mycosorb, Ms) adsorbenta čijom primenom nije došlo do zaštitnog efekta, u tkivnim isečcima jetre, creva i Fabricijeve burze kod brojlera koji su putem hrane dobijali T-2 toksin i mešoviti adsorbent (Mycofix, Mf), zapaža se uglavnom očuvana struktura ispitivanih organa