Al-Herz W

Böttger EC

Casanova JL

Costa-Carvalho BT

de Beaucoudrey L

Fine PE

Hesseling AC

Jorge Andrade Pinto

Lilian Martins Oliveira Diniz

Maria das Graças Rodrigues de Oliveira

Rosenzweig SD

Sadeghi-Shanbestari M

Santos A

Sicevic S

Silvana Spindola de Miranda

Talbot EA

Tiago Guimarães

Jornal Brasileiro de Pneumologia

We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The patient was treated with a special pharmacological regimen involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and IFN-γ, after which there was complete resolution of the lesions.</jats:p

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Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect

http://www.scielo.br/pdf/jbpneu/v40n2/1806-3713-jbpneu-40-02-00188.pdf

Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect

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