Maternal recreational drug use may be associated with the development of fetal malformations such as gastroschisis, brain and limb defects, the aetiology due to vascular disruption during organogenesis. Using forensic hair analysis we reported evidence of recreational drug use in 18% of women with a fetal gastroschisis. Here we investigate this association in a variety of fetal malformations using the same method

A Orrico

Amie Wilson

Andrew Holloway

Anna L. David

Argyro Syngelaki

Brian Sommerlad

C Bower

CP Torfs

D Markov

ES Draper

J Bays

J Klein

J Kline

JJ Morrison

JJ Nora

KA Godwin

Katsuaki Suzuki

KH Tan

Kypros Nicolaides

Louise Thomasson

Lyn S. Chitty

M Kashiwagi

M Villain

MA Huestis

MA Plessinger

ML Colado

MM Werler

N He

N Miyazawa

R Dominguez

RF Hume Jr

Roshni R. Patel

S Paranjothy

SE Lipshultz

T Grant

TH Beaty

V Spiehler

William Martin

WS Webster

Y Nakahara

Y Yamamoto

PLoS ONE

PubMed

David, AL

Holloway, A

Thomasson, L

Syngelaki, A

Nicolaides, K

Patel, RR

Sommerlad, B

Wilson, A

Martin, W

Chitty, LS

UCL Discovery

A case-control study of maternal periconceptual and pregnancy recreational drug use and fetal malformation using hair analysis.

Objective: Maternal recreational drug use may be associated with the development of fetal malformations such as gastroschisis, brain and limb defects, the aetiology due to vascular disruption during organogenesis. Using forensic hair analysis we reported evidence of recreational drug use in 18% of women with a fetal gastroschisis. Here we investigate this association in a variety of fetal malformations using the same method. Methods: In a multi-centre study, women with normal pregnancies (controls) and those with fetal abnormalities (cases) gave informed consent for hair analysis for recreational drug metabolites using mass spectrometry. Hair samples cut at the root were tested in sections corresponding to 3 month time periods (pre and periconceptual period). Results: Women whose fetus had gastroschisis, compared to women with a normal control fetus, were younger (mean age 23.78±SD4.79 years, 18-37 vs 29.79±SD6 years, 18-42, p = 0.00001), were more likely to have evidence of recreational drug use (15, 25.4% vs 21, 13%, OR2.27, 95thCI 1.08-4.78, p = 0.028), and were less likely to report periconceptual folic acid use (31, 53.4% vs 124, 77.5%, OR0.33, 95thCI 0.18-0.63, p = 0.001). Age-matched normal control women were no less likely to test positive for recreational drugs than women whose fetus had gastroschisis. After accounting for all significant factors, only young maternal age remained significantly associated with gastroschisis. Women with a fetus affected by a non-neural tube central nervous system (CNS) anomaly were more likely to test positive for recreational drugs when compared to women whose fetus was normal (7, 35% vs 21, 13%, OR3.59, 95th CI1.20-10.02, p = 0.01). Conclusions: We demonstrate a significant association between non neural tube CNS anomalies and recreational drug use in the periconceptual period, first or second trimesters, but we cannot confirm this association with gastroschisis. We confirm the association of gastroschisis with young maternal age.</p

David, Anna L.

Holloway, Andrew

Thomasson, Louise

Syngelaki, Argyro

Nicolaides, Kypros

Patel, Roshni R.

Sommerlad, Brian

Wilson, Amie

Martin, William

Chitty, Lyn S.

University of Birmingham Research Portal

A case-control study of maternal periconceptual and pregnancy recreational drug use and fetal malformation using hair analysis

OBJECTIVE: Maternal recreational drug use may be associated with the development of fetal malformations such as gastroschisis, brain and limb defects, the aetiology due to vascular disruption during organogenesis. Using forensic hair analysis we reported evidence of recreational drug use in 18% of women with a fetal gastroschisis. Here we investigate this association in a variety of fetal malformations using the same method. METHODS: In a multi-centre study, women with normal pregnancies (controls) and those with fetal abnormalities (cases) gave informed consent for hair analysis for recreational drug metabolites using mass spectrometry. Hair samples cut at the root were tested in sections corresponding to 3 month time periods (pre and periconceptual period). RESULTS: Women whose fetus had gastroschisis, compared to women with a normal control fetus, were younger (mean age 23.78 ± SD4.79 years, 18-37 vs 29.79 ± SD6 years, 18-42, p = 0.00001), were more likely to have evidence of recreational drug use (15, 25.4% vs 21, 13%, OR2.27, 95thCI 1.08-4.78, p = 0.028), and were less likely to report periconceptual folic acid use (31, 53.4% vs 124, 77.5%, OR0.33, 95thCI 0.18-0.63, p = 0.001). Age-matched normal control women were no less likely to test positive for recreational drugs than women whose fetus had gastroschisis. After accounting for all significant factors, only young maternal age remained significantly associated with gastroschisis. Women with a fetus affected by a non-neural tube central nervous system (CNS) anomaly were more likely to test positive for recreational drugs when compared to women whose fetus was normal (7, 35% vs 21, 13%, OR3.59, 95th CI1.20-10.02, p = 0.01). CONCLUSIONS: We demonstrate a significant association between non neural tube CNS anomalies and recreational drug use in the periconceptual period, first or second trimesters, but we cannot confirm this association with gastroschisis. We confirm the association of gastroschisis with young maternal age

Anna L David

Roshni R Patel

Lyn S Chitty

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A Case-Control Study of Maternal Periconceptual and Pregnancy Recreational Drug Use and Fetal Malformation Using Hair Analysis

http://discovery.ucl.ac.uk/1453996/1/journal.pone.0111038.pdf

A Case-Control Study of Maternal Periconceptual and Pregnancy Recreational Drug Use and Fetal Malformation Using Hair Analysis

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UCL Discovery

University of Birmingham Research Portal

Directory of Open Access Journals

Crossref

University of Birmingham Research Portal