A Galarneau

AJ Chen

B He

BM Stiles

CA Chenard

D Larocque

E Tili

EP Veer van der

FR Talukdar

FY Zong

G Yang

Haizhu Song

J Pilotte

Jing Chen

Jun Yi

K Bockbrader

K Taniguchi

KL Kong

L Liu

L Saccomanno

Li Jin

Longbang Chen

M Kano

MP Hall

N Akanuma

N Rosenfeld

R Siegel

RJ Hardy

S Lamouille

Siqi Han

T Lin

W Lu

X Fu

Xiaolong Liu

XL Wu

Y Bian

Y Hiyoshi

Y Zhao

YF Xu

Z Chen

Zhenyue He

Molecular Cancer

Abstract
                Background
                Dysregulation of microRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis. MiR-143-3p has been identified to function as a tumor suppressor in several tumors, but the role of miR-143-3p in esophageal squamous cell carcinoma (ESCC) has not been intensively investigated. Our aim was to evaluate the potential role of miR-143-3p in the progression of ESCC.
              
                Methods
                The expression levels of miR-143-3p and QKI-5 protein were measured in 80 resected ESCC tumor specimens and the clinicopathological significance of these levels determined. We also investigated the role of miR-143-3p in the regulation of QKI-5 expression in ESCC cell lines both in vivo and in vitro.
              
                Results
                MiR-143-3p levels were decreased in ESCC clinical samples and low expression of miR-143-3p was significantly associated with poor prognosis in ESCC patients. Ectopic expression of miR-143-3p suppressed proliferation and induced apoptosis in ESCC cells both in vivo and in vitro. Ectopic expression of miR-143-3p also reduced the metastatic potential of cells by selectively regulating epithelial–mesenchymal transition regulatory proteins. Furthermore, QKI-5 isoform was upregulated in ESCC tissues and was a direct target of miR-143-3p. Lastly, re-introduction of QKI-5 expression abrogated the inhibitory effects of miR-143-3p on ESCC cell proliferation and motility.
              
                Conclusions
                Our results demonstrate that miR-143-3p acts as a tumor-suppressor by targeting QKI-5 in ESCC, suggesting that miR-143-3p is a potential therapy for the treatment of ESCC.
              </jats:sec

Crossref

RETRACTED ARTICLE: MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma

https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-016-0533-3?site=molecular-cancer.biomedcentral.com

MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma

MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma

Abstract

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