M Khullar

R Walker Minz

S Singh

V Mahajan

Pediatric Rheumatology

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BioMed CentralPage 1 of 1(page number not for citation purposes)Pediatric RheumatologyOpen AccessPoster presentationSerum and urine nitric oxide levels in children with Henoch-Schonlein Purpura during activity and remission – a study from North IndiaV Mahajan, S Singh*, M Khullar and R Walker MinzAddress: Post Graduate Institute of Medical Education and Research, Chandigarh, India* Corresponding author    ObjectiveTo compare serum and urine reactive nitrogen intermedi-ates (RNI) and citrulline levels in children with Henoch-Schonlein Purpura (HSP) during activity and remission.MethodsThe study group consisted of 14 children with biopsyproven HSP. We measured serum and urine RNI and cit-rulline levels by spectrophotometry in the active phaseand after remission.ResultsSerum RNI levels were 303.95 ± 221.44 nmol/ml in chil-dren with active HSP and 72.57 ± 26.56 nmol/ml duringremission, the differences being statistically significant (p= 0.002). Mean urine RNI levels in children with activeHSP were significantly higher than that seen during remis-sion (3.25 ± 1.80 vs. 1.68 ± 0.65 nmol/ml; p = 0.003).Similarly, serum citrulline levels during disease activitywere 790.65 ± 707.87 nmol/ml as compared to 281.49 ±307.29 nmol/ml at the time of remission, the differencesbeing statistically significant (p = 0.002). Mean urine cit-rulline levels in children with active disease was 1969.94± 1655.42 nmol/ml as compared to 1099.34 ± 955.82nmol/ml in children with remission, (p = 0.007).ConclusionSerum and urine RNI and citrulline levels were signifi-cantly higher during the active phase of HSP. These find-ings suggest that nitric oxide may perhaps have a role inthe pathogenesis of HSP. Further, these laboratory param-eters could be of value in monitoring disease activity.from 15th Paediatric Rheumatology European Society (PreS) CongressLondon, UK. 14–17 September 2008Published: 15 September 2008Pediatric Rheumatology 2008, 6(Suppl 1):P261 doi:10.1186/1546-0096-6-S1-P261<supplement> <title> <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> </title> <editor>Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/PDF/1546-0096-6-S1-full.pdf">here</a>.</note> </supplement>This abstract is available from: http://www.ped-rheum.com/content/6/S1/P261© 2008 Mahajan et al; licensee BioMed Central Ltd. 

Serum and urine nitric oxide levels in children with Henoch-Schonlein Purpura during activity and remission – a study from North India

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Serum and urine nitric oxide levels in children with Henoch-Schonlein Purpura during activity and remission � a study from North India

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