Benedict RG

Bonten MJ

Brown MR

Clinical and Laboratory Standards Institute (CLSI)

European Medicines Agency

John EB

Karvanen MC

Mammina C

Meletis G

Tan TY

Zagorianou A


            SUMMARY
            Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.
          </jats:sec

Laurent Poirel

Aurélie Jayol

Patrice Nordmann

Crossref

Clinical Microbiology Reviews

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

http://doc.rero.ch/record/288696/files/nor_paa.pdf

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

Abstract

Similar works

Full text

Available Versions

Crossref