Anaemia and cancer : oral or intravenous iron ?

Abstract

peer reviewedAnaemia and absolute or functional iron deficiency (ID) are common issues among cancer patients, with the prevalence of ID ranging from 32% to 60%. Most randomised clinical trials have shown superior efficacy of IV iron over oral or no iron supplementation in anaemic cancer patients receiving erythropoiesis-stimulating agents. Intravenous iron supplementation reduced blood transfusions, increased haemoglobin, and improved quality of life. At recommended doses, IV iron is well tolerated, and allergic reactions are exceedingly rare with modern formulations. Oral iron is often poorly tolerated and this can lead to compliance issues