Carru

Charlton

Daniel

Dobsikova

Eder

Fujioka

Hadnagy

Haluzova

Helena Modrá

Hinfray

Hoffmann

Hooghe

Ivana Mikuliková

Jeon

Kinnberg

Monserrat

Murr

Petr Maršálek

Sghiri

Smutna

Stang

Stiller-Winkler

Wang

Werner-Felmayer

Zdeňka Svobodová

Ziegler

Acta Veterinaria Brno

Neopterin and biopterin are often used as markers of cell mediated immunity. The aim of this study was to evaluate the effect of prochloraz on neopterin and biopterin concentrations in blood plasma of common carp as possible indicators for monitoring perturbations of the immune system caused by xenobiotics like pesticides. Prochloraz is a widely used imidazole fungicide in horticulture and agriculture. A total of 60 juvenile common carp were divided into four groups of 15 fish and exposed to prochloraz at concentrations of 0, 50, 150 and 380 µg·l-1, respectively. The total length of exposure was 28 days. Neopterin and biopterin concentrations were determined by reverse phase high performance liquid chromatography with fluorescence detection. Our results indicated that concentrations of neopterin (25 ± 7.6 nmol·l-1) and biopterin (190 ± 29 nmol·l-1) in plasma of untreated common carp were comparable with those in mammals. Neopterin concentrations significantly (P &lt; 0.01) increased after exposure to prochloraz in comparison to non-exposed fish, while biopterin concentrations were not influenced by exposure to prochloraz. This study contains new data on neopterin and biopterin concentrations in fish plasma and investigates neopterin and biopterin in their non-traditional role as markers of cell mediated immunity of fish associated with pesticide exposure.</jats:p

Ivana Mikulíková

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Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

https://actavet.vfu.cz/media/pdf/avb_2014083020101.pdf

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

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