Sur l'action antioedème de l'escine

Abstract

Anti-inflammatory activity of escine. - Escine is one of the most active saponines extracted from Aesculum hippocastanum. As a pure compound, escine-Na inhibits exsudative oedema induced locally in the rat skin by dextran (MW (0000). This inhibition is due, for a small part, to the release of adrenaline by adrenal medulla; for an other part, to an interaction with glyco-cortico-steroids from the adrenal cortex and, finally, to direct potent vasoconstriction