Anti-inflammatory activity of escine. - Escine is one of the most active saponines
extracted from Aesculum hippocastanum. As a pure compound, escine-Na inhibits
exsudative oedema induced locally in the rat skin by dextran (MW (0000). This
inhibition is due, for a small part, to the release of adrenaline by adrenal medulla; for
an other part, to an interaction with glyco-cortico-steroids from the adrenal cortex and,
finally, to direct potent vasoconstriction