Alvarez-Leite JI

Avgerinos DV

Barrow CJ

Charles P

Compston JE

Costa TMRL

Dano P

Eddy RL

Flores L

Goldner WS

Halverson JD

Hamoui N

Hylander E

Jones KB

Nunan TO

Parfitt AM

Rannem T

Riedt CS

Santos EF

Santos TD

Sellin JH

Silveira-Júnior S

Stein EM

Vasconcelos R.S.

Weber M

Williams SE

Zittel TT

ABCD : Arquivos Brasileiros de Cirurgia Digestiva

ABSTRACT  Introduction: Bariatric surgery is considered the most effective tool in the control and treatment of severe obesity, but patients undergoing this procedure are at increased risk of developing nutritional deficiencies by limiting the intake and absorption of many nutrients.  Objective: To assess the impact of vitamin D deficiency and calcium in bone in patients after gastric bypass in Roux-en-Y, pointing directly at the type of administration, doses and effects after surgery.  Method: Was conducted a systematic review with articles related to the topic of the last 10 years searched in PubMed (US National Library of Medicine National Institutes of Health, Medline, Lilacs, Scielo and Cochrane using the headings "bariatric surgery", "bone", "obesity", "vitamin D '', "calcium" AND "absorption". Exclusion criteria to research on animals, smokers, pregnant women and patient treated with bisphosphonates.  Results: Five articles were included in this review. All refer that bariatric surgery can lead to nutritional deficiencies and poor absorption of fats and fat-soluble vitamins and other micronutrients such as calcium.  Conclusion: Patients submitted to RYGB should make use of multivitamins and minerals especially vitamin D and calcium to prevent bone fractures. Monitoring, treatment and control of risk factors are essential to prevent complications after this operation.</jats:p

Jefry Alberto Vargas CABRAL

Gabriela Pereira de SOUZA

Juliana de Almeida NASCIMENTO

Luis Fernando SIMONETI

Carolina MARCHESE

Silvia Helena de Carvalho SALES-PERES

Crossref

ABCD Arq Bras Cir Dig Review Article2016;29(Supl.1):120-123DOI: /10.1590/0102-6720201600S10029IMPACT OF VITAMIN D AND CALCIUM DEFICIENCY IN THE BONES OF PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEWImpacto da deficiência da vitamina d e cálcio em ossos de pacientes submetidos à cirurgia bariátrica: uma revisão sistemáticaJefry Alberto Vargas CABRAL1; Gabriela Pereira de SOUZA2; Juliana de Almeida NASCIMENTO1; Luis Fernando SIMONETI2; Carolina MARCHESE1; Silvia Helena de Carvalho SALES-PERES3From the 1Programa de Pós-Graduação em Odontologia em Saúde Coletiva; 2Programa de Pós-Graduação em Ciências Biológicas; e 3Departamento de Odontopediatria, Ortodontia e Saúde Coletiva, Faculdade de Odontologia de Bauru, Universidade de São Paulo (1Postgraduate Program in Public Health Dentistry; 2Postgraduate Program in Biological Sciences; and 3Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo), SP, Brazil. HEADINGS - Bariatric surgery. Obesity. Absorption. Bone. Vitamin D. CalciumABSTRACT – Introduction: Bariatric surgery is considered the most effective tool in the control and treatment of severe obesity, but patients undergoing this procedure are at increased risk of developing nutritional deficiencies by limiting the intake and absorption of many nutrients. Objective: To assess the impact of vitamin D deficiency and calcium in bone in patients after gastric bypass in Roux-en-Y, pointing directly at the type of administration, doses and effects after surgery. Method: Was conducted a systematic review with articles related to the topic of the last 10 years searched in PubMed (US National Library of Medicine National Institutes of Health, Medline, Lilacs, Scielo and Cochrane using the headings “bariatric surgery”, “bone”, “obesity”, “vitamin D ‘’, “calcium” AND “absorption”. Exclusion criteria to research on animals, smokers, pregnant women and patient treated with bisphosphonates. Results: Five articles were included in this review.  All refer that bariatric surgery can lead to nutritional deficiencies and poor absorption of fats and fat-soluble vitamins and other micronutrients such as calcium. Conclusion: Patients submitted to RYGB should make use of multivitamins and minerals especially vitamin D and calcium to prevent bone fractures. Monitoring, treatment and control of risk factors are essential to prevent complications after this operation. RESUMO – Introdução: A cirurgia bariátrica é considerada o tratamento mais eficaz no controle e tratamento da obesidade severa; porém, indivíduos submetidos a este procedimento apresentam maior risco de desenvolver deficiências nutricionais pela limitação na ingestão e absorção de muitos nutrientes.  Objetivo: Avaliar o impacto da deficiência de vitamina D e do cálcio ósseo de pacientes após gastroplastia em Y-de-Roux, relacionando tipo de administração, dose e efeito pós-cirúrgico. Método: Realizou-se revisão sistemática com artigos relacionados ao tema dos últimos 10 anos e pesquisados na PubMed (US National Library of Medicine National Institutes of Health, Medline, Lilacs, Scielo e Cochrane usando os descritores “bariatric surgery”, “bone”, “obesity”, “ vitamin D’’, “calcium’’ AND “absortion”. Foram excluídos os estudos em animais, fumantes, grávidas ou gestantes e indivíduos que ingeriram bisfosfonatos. Resultados: Foram incluídos ao final cinco artigos. Todos referem que a cirurgia bariátrica pode levar à deficiências nutricionais como má absorção de gorduras, vitaminas lipossolúveis, micronutrientes e cálcio. Conclusão: Os pacientes submetidos ao RYGB devem fazer uso de polivitamínicos e minerais principalmente a vitamina D e o cálcio para evitar fraturas ósseas. Monitoramento, tratamento e controle dos fatores de risco são essenciais para prevenir estas complicações após a operação.Correspondencia: Silvia Helena de Carvalho Sales-PeresE-mail: shcperes@usp.brFinancial source: noneConflicts of interest: noneReceived for publication: 17/11/2015Accepted for publication: 15/03/2016DESCRITORES: Cirurgia bariátrica. Obesidade. Absorção. Vitamina D. Cálcio.ABCDDV/1219INTRODUCTIONSince the development of bariatric surgery, many surgical methods for the treatment of morbid obesity have been developed over the past decades. The Roux-Y gastric bypass (RYGB) is an operation which is considered gold standard treatment alternative for severe obesity3 because it promotes less severe absorption and complications than traditional malabsorption procedures, such as jejunoileal bypass3,15,26. The malabsorption procedures have been recognized as a risk factor for the development of bone5,8,12,17,28 disease as a result of modification of calcium (Ca) metabolism and impairment of its absorption4,7,14,16,18,22,23. Only a few studies have investigated the absorption of Ca prospectively in patients with jejunoileal bypass and showed that absorption decreases by 50% after surgery7,14,22. To our knowledge, the change in Ca absorption after RYGB surgery has not been addressed previously. In addition, inadequate intake Ca is common after gastric bypass1,20, which can also contribute to altered bone loss6.Understand the postoperative RYGB decrease in absorption and calcium intake and investigate the doses, routes of administration, the time of drug therapy and its effects on bone, were the objectives of this review.120 ABCD Arq Bras Cir Dig 2016;29(Supl.1):120-123METHODSWas adopted the PICO method (population, intervention, comparison and outcome) to elaborate the answer for this question “How is bone loss in patients who undergo bariatric surgery and what supplements help to decrease this loss?”Were enrolled obese patients who had bone loss and or BMI from 35-39.9 kg/m2 with comorbidities and ≥40 kg/m2 (population); patients submitted to RYGB by laparoscopy or laparotomy (intervention); eutrophic patients with 18.5-24.9 kg/m2 (comparison); deficiency of vitamin D and calcium, possible presence of fractures (outcome).Eligibility criteria for study inclusionInclusion criteria were: all studies; patients from 15-70 years; BMI from 35-39.9 kg/m2 with comorbidities and ≥40 kg/m2; postoperative at least of three months; laparoscopic or laparotomic RYGB. Exclusion criteria were: pregnant women or women in stage of lactation; smoking or former smoker; individuals treated with bisphosphonates; studies in animals.Types of outcomePrimary result was focused in vitamin D and calcium deficiency; however, was explored possible bone fractures after bariatric surgery. As secondary results, was searched relationship between the type of administration and the body’s efficiency in absorbing medication; and the doses and its effects on the maintenance or recovery of bone loss after bariatric surgery.Search strategyPubMed/Medline, Lilacs, Scielo and Cochrane were used crossing the headings “bariatric surgery”, “bone”, “obesity”, “vitamin D ‘’, “calcium” “AND” “absorption”. After the search, analysis of the title, reading the abstract and finally the complete reading of the articles has been made.Screening methodsFour reviewers made the primary research for titles and abstracts. Afterwards, the same reviewers assessed the full manuscript observing compliance with the inclusion/exclusion criteria or those with insufficient data in the title and abstract. Any disagreement was resolved by discussion between the reviewers and an independent reviewer conducted a manual search.When the results of a study were published more than once and the results were presented in various publications by the same author, they were included only once in this review.RESULTSFlowchart (Figure 1) illustrates the strategy of search and selection process of the 13 titles identified by electronic search. Six were discarded by titles and abstracts, resulting in seven studies, which underwent full-text analysis. Afterwards, two publications were excluded for not meeting the inclusion criteria. At the end, remained five articles that were analyzed for this review. Study descriptionTable 1 shows the methodological characteristics of selected studies. Of the five articles, three corresponded to prospective cohort studies; two used laparoscopic approach and one enrolled only women; there was one case report; one case series. All assessed the nutritional status and bone fractures, routes of administration, as well as the respective dosage of vitamin D and calcium; one article evaluated the parathyroid hormone and its influence on bone reabsorption in RYGB.FIGURE 1 -  Flowchart describing the strategy of search and selection processDISCUSSIONThe results of this systematic review are based in five publications. The research did not identify bone fractures in patients undergoing bariatric surgery; however, showed high deficiencies in vitamin D and calcium in the bones. The studies showed the different routes of administration, and the results, answering the various questions about deficiencies that arise in the bone tissue due to dosage and effectiveness, according to the route of administration.After bariatric surgery all investigations reported results with deficiency in the bones of patients, regardless of the type of bariatric surgery (videolaparoscopy or laparotomy). All mentioned intake of vitamin D and calcium in the diet, via tablets or injections in different dosage. None of them presented complete elimination of bone loss, but showed a significant difference in bone resorption, mainly by parathyroid hormone, which increases the activity of osteoclasts leading to the destruction of the cortical bone, showing also marked deficiency of vitamin D10,23, weakening the bones and the possibility of fractures in postoperative period. Avgerinos et al., 20072 in his important prospective cohort in individuals of both genders for two years have shown the importance of vitamin D supplementation to prevent the decrease of calcium in the bones. Other authors also showed high deficiency of vitamin D in patients after this surgery 2,9,10,19,25,27 .Researchers analyzed women in pre- and postmenopausal IMPACT OF VITAMIN D AND CALCIUM DEFICIENCY IN THE BONES OF PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW121ABCD Arq Bras Cir Dig 2016;29(Supl.1):120-123stage showing that there was no significant difference in calcium absorption deficiency and even differences in relationship to the type of surgery20,25,29.According to this review the types of administration and dosage had no relationship or relevance over time on drug therapy. However, showed no direct relation to the postoperative bone loss. Vasconcelos et al. consider the calcium intake in the diet at 600 mg and supplemented with 200 mg in tablets during the 22 months in the operated group. Although significantly higher than in the non-operated group was still lower than recommended levels for these patients, that should be between 1000-1800 mg/day11,13,24. Intake of vitamin D (500 IU) was also below the recommended levels.It can be inferred from that the postoperative vitamin supplementation should not only consist of multivitamins, because most do not contain the calcium and vitamin D required and recommended to be taken every day. The above changes may increase during postoperative and preoperative screening; care should be taken to prevent the changes in bone metabolism. Suitable supplementation of vitamins and minerals is essential to prevent or minimize bone metabolic complications that can occur after RYGB25.An important factor in addition to vitamin D supplementation and calcium that may affect bone change in these patients is the age, besides the differences between women in premenopausal and postmenopausal women that need specific approach.There are other factors that can influence directly and contribute to bone resorption, which is a chronic deficiency of vitamin D, inadequate calcium intake and secondary hyperparathyroidism appearing sometimes in obese. The parathyroid hormone also increases the activity of osteoclasts leading to bone cortical destruction to compensate for the decrease of serum Ca10.In relation to bone density and fracture prevalence no significant differences in the studies were found. It is possible that the relatively short follow-up contributed to the lack of identification of bone fracture. Future long-term studies should be conducted to better clarify the bone complications in these patients.CONCLUSIONSPatients undergoing RYGB should make use of multivitamins and minerals especially calcium and vitamin D to prevent bone fractures. Monitoring, treatment and control of risk factors are essential to prevent these complications after the surgery.REFERENCES1. Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric surgery. Curr Opin Clin Nutr Metab Care.2004;7:569–75. 2. Avgerinos DV, Leitman IM, Martínez RE, Liao EP. Evaluation of markers for calcium homeostasis in a population of obese adults undergoing gastric bypass operations. J Am Coll Surg. 2007;205(2):294-7.3.  Barrow CJ. Roux-en-Y gastric bypass for morbid obesity. AORN J. 2002;76:(590)593–604. 4. Charles P, Mosekilde L, Sondergard K, Jensen FT. Treatment with high-dose oral vitamin D2 in patients with jejuno-ileal bypass for morbid obesity. Effects on calcium and magnesium metabolism, vitamin D metabolites, and faecal lag time. Scand J Gastroenterol. 1984;19:1031–8. Reference (year)Type of studyStudy locationPeriod of follow-upN * Tipe of surgery **  age Sex***Type of medicationType of administration Individual DosesTime of medical therapyConclusionVasconcelos RS et. al 2010 25Case Series BrazilFrom 7 to 22 monthsn=29 RYGB >18 years FCalcium e Vitamin D(tablets  and diet) people600mg Diet +200mg tablet of Ca and 500 IU Vitamin D (per day)From 7 to 22 monthsThere were no significant differences between the average bone mass density and prevalence of vertebral fractures in both groups.Flores L. et. al 2010 10Prospective cohort studyEspain 1 year n=222 RYGBL 18-65 Years F e MCalcium and Vitamin D(tablets) people1,200 mg Ca and 800 IU Vitamin D (per day)4,8 e 12 monthsThe parathyroid hormone leads cortical bone destruction and improving serum Ca. 80% of patients have vitamin D deficiency but not bone fractures.Williams SE. et al 2008 27 Case studyUnited States 2 years N=1 RYGB56 years FCálcium vitamin D (tablets) person500mg Ca and 400 IU (per day)2 yearsAfter 2 years the patient showed no fracture or risk to bone fracture level. Avgerinos DV. et al 2007 2A prospective cohort studyUnited States 2 years N=444 (M=91 F=353)RYGB 21-64 years M e FCálciume vitamin D (tablets) people1,200 mg Ca and 800IU VitaminaD1.8 yearsTotal calcium decreases in body related mobilization of bone. Supplementation with vitamin D prevent the decrease in bone calcium.Riedt CS et. al 2006 19A prospective cohort study Unites States 6 months N=21 RYGB and RYGBL (5:open field and 16 laparoscopy) 29-62 years  F Cálcium Vitamin D (tablets, diet and injected)  people Diet, 1,000 mg of Ca and 400 IU Vitamin D  6 monthsLow Ca absorption after surgery, being considered markers of bone resorption (60 to 200%). There was a higher bone resorption than bone formationTABLE 1 - Methodological characteristics of the selected studies, type of interventions and resultsREVIEW ARTICLE122 ABCD Arq Bras Cir Dig 2016;29(Supl.1):120-1235. Compston JE, Horton LW, Laker MF. Bone disease after jejuno-ileal bypass for obesity. Lancet.1978;2:1–4. 6. Costa TMRL. Impact of deficient nutrition in bone mass after bariatric surgery. Arq Bras Cir Dig. 2016;29:38-42.7. Dano P, Christiansen C. Calcium malabsorption and absence of bone decalcination following intestinal shunt operation for obesity. A comparison of two types of operation. Scand J Gastroenterol. 1978;13:81–5.8. Eddy RL. Metabolic bone disease after gastrectomy. Am J Med. 1971;50:442–9. 9. Flores L , Jesús MO. Calcium and Vitamin D Supplementation after Gastric Bypass Should Be Individualized to Improve or Avoid Hyperparathyroidism. Obesity Surgery. 2010;20(6):738-743.10. Flores L, Osaba MJM, Andreu A, Moizé V, Rodríguez L,  Vidal J. Calcium and vitamin D supplementation after gastric bypass should be individualized to improve or avoid hyperparathyroidism. Obes surg. 2010;20(6):738-743.11. Goldner WS, Stoner JA, Thompson J, Taylor K, Larson L, Erickson J. Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg. 2008;18(2):145-50. 12. Halverson JD, Teitelbaum SL, Haddad JG, Murphy WA. Skeletal abnormalities after jejunoileal bypass. Ann Surg. 1979;189:785–90. 13. Hamoui N, Anthone G, Crookes PF. Calcium metabolism in the morbidly obese. Obes Surg. 2004;14(1):9-12. 14. Hylander E, Jarnum S, Kempel K, Thale M. The absorption of oxalate, calcium, and fat after jejunoileal bypass. A prospective study. Scand J Gastroenterol. 1980;15:343–8. 15. Jones KB. Jr Bariatric surgery–where do we go from here? Int Surg. 2004;89:51–7. 16.  Nunan TO, Compston JE, Tonge C. Intestinal calcium absorption in patients after jejuno-ileal bypass or small intestinal resection and the effect of vitamin D. Digestion. 1986;34:9–14. 17. Parfitt AM, Miller MJ, Frame B. Metabolic bone disease after intestinal bypass for treatment of obesity. Ann Intern Med. 1978;89:193–9. 18. Rannem T, Hylander E, Jarnum S. Calcium absorption and bone mineral content in patients subjected to ileal bypass because of familial hypercholesterolaemia. Scand J Gastroenterol. 1990;25:897–905.19. Riedt CS, Brolin RE, Sherrell RM, Field MP, Shapses SA. True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring). 2006;14(11):1940-8.20. Santos TD, Burgos MG, de Lemos Mda C, Cabral PC. Clinical and nutritional aspects in obese women during the first year after roux-en-y gastric bypass. Arq Bras Cir Dig. 2015;28:(Suppl 1)56-60.21.  Santos EF. Partial gastrectomy associated to anterior truncal vagotomy: alterations in metabolism of the calcium. Experimental study in rats. Arq Bras Cir Dig. 2009;22(2):105-109.22. Sellin JH, Meredith SC, Kelly S, Schneir H, Rosenberg IH. Prospective evaluation of metabolic bone disease after jejunoileal bypass. Gastroenterology. 1984;87:123–9. 23. Silveira-Júnior S, de Albuquerque MM, do Nascimento RR, da Rosa LS, Hygidio Dde A, Zapelini RM. Nutritional repercussions in patients submitted to bariatric surgery. Arq Bras Cir Dig. 2015;28(1):48-52.24. Stein EM, Straint G, Sinha N, Ortiz D, Pomp A, MacMahon DJ, et al. Vitamin D insufficiency prior to bariatric surgery: risk factors and a pilot treatment study. Clin Endocrinol (Oxf). 2009;71:176-83. 25. Vasconcelos R.S., Renata S. Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-Y gastric bypass for the treatment of obesity. Arq Bras Endocrinol Metab. 2010;54(2):233-238. 26. Weber M, Muller MK, Bucher T. Laparoscopic gastric bypass is superior to laparoscopic gastric banding for treatment of morbid obesity. Ann Surg. 2004;240:975–82. 27. Williams SE, Cooper K, Richmond B, Schauer P. Perioperative management of bariatric surgery patients: focus on metabolic bone disease. Cleve Clin J Med. 2008;75(5):333-4, 336, 338passim.28. Zittel TT, Zeeb B, Maier GW. High prevalence of bone disorders after gastrectomy. Am J Surg.1997;174:431–8. IMPACT OF VITAMIN D AND CALCIUM DEFICIENCY IN THE BONES OF PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW123ABCD Arq Bras Cir Dig 2016;29(Supl.1):120-123

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

IMPACT OF VITAMIN D AND CALCIUM DEFICIENCY IN THE BONES OF PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW

http://www.scielo.br/pdf/abcd/v29s1/0102-6720-abcd-29-s1-00120.pdf

IMPACT OF VITAMIN D AND CALCIUM DEFICIENCY IN THE BONES OF PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW

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