A Nag

B Brunot

B Joseph

BG Ericzon

CG Groth

EJ Gane

G Shah

GB Daniel

H Gjertsen

HA Kansoul

KK Bhargava

M Kaibori

NL Ascher

PH Brown

T Mochizuki

TL Wright

V Konig

W de Graaf

EJNMMI Research

Abstract
          
            Background
            Hepatobiliary scintigraphy using 99mTc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diverging effect of cyclosporin A (CSA) and tacrolimus (TAC) on the HEF, we compared the HEF with biochemical and histological parameters in LTx patients receiving either CSA or TAC.
          
          
            Methods
            Thirty-nine adult patients who underwent LTx due to hepatitis C virus (HCV) cirrhosis were evaluated. All patients underwent a 3-month and 1-year follow-up that included hepatobiliary scintigraphy and biochemistry tests. Liver biopsy was performed at 1 year. These clinical parameters were compared between the two groups, TAC (n = 15) and CSA (n = 24).
          
          
            Results
            The average HEF was significantly lower in the CSA group compared to the TAC group both at 3 months and 1 year after LTx. The liver biochemistry tests, average donor and recipient age, average cold ischemia time (CIT), and a clearance were comparable in the two groups. The TAC group had more inflammation than the CSA group. Moreover, three patients who converted from CSA to TAC increased their HEF values.
          
          
            Conclusions
            CSA-treated patients presented a lower HEF value on hepatobiliary scintigraphy in spite of comparable liver function by traditional measurements indicating a decrease on HEF values by CSA.
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Anastasios Kaxiras

Shinji Yamamoto

Gunnar Söderdahl

Annika Wernerson

Rimma Axelsson

Bo-Göran Ericzon

Crossref

Cyclosporin A, but not tacrolimus, negatively affects the hepatic extraction fraction of hepatobiliary scintigraphy in liver transplant recipients

https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-014-0073-z?site=ejnmmires.springeropen.com

Cyclosporin A, but not tacrolimus, negatively affects the hepatic extraction fraction of hepatobiliary scintigraphy in liver transplant recipients

Abstract

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