Biljana Krivic

Dejan Markovic

Dijana Jovanovic

Djordje Ugrinovic

Jelena Velickovic

Nebojsa Ladjevic

Nevena Kalezic

Vladan Zivaljevic

Srpski Arhiv za Celokupno Lekarstvo

Introduction. Anaesthesia affects kidney function by reducing the renal blood
   flow and glomerular filtration rate. As chronic renal failure (CRF)
   significantly influences drug metabolism and elimination, we studied the
   effects of rocuronium bromide (RB) in patients with CRF. Objective. The aim
   of the study was to examine whether, when using RB in patients with CFR,
   there are differences regarding the onset time of neuromuscular block (NMB)
   development, duration time, speed of recovery and cumulative effects of RB.
   Methods. Prospective study included 60 patients who underwent urologic
   surgery procedures. The patients were divided into 3 groups: the first group
   (G1) - 20 patients with CRF and residual dieresis, the second group (G2) - 20
   patients with CRF and without dieresis, and third group (G3) - 20 patients
   with normal renal function (control group). During surgery RB was
   administrated for muscle paralysis in all patients. Train-of-four (TOF) Guard
   acceleromyography was used for NMB monitoring. Results. Onset time in three
   groups was 132.3 s; 139.5 s and 113.2 s (r&lt;0.01). Duration of intubation dose
   was the same in G1 and G2 (28.9 minutes), while in the third group it was
   27.2 minutes (r&gt;0.05). The number of RB repeated doses was 3-8, 3-7 and 4-8
   (r&gt;0.05). The duration time until spontaneous recovery was 31.8, 31.6 and
   29.8 minutes (r&gt;0.01). The recovery index was 16.8, 16.7 and 10.6 minutes
   (r&lt;0.001). The duration time from the last dose of RB to extubation was 74.5,
   74.8 and 58.9 minutes (r&lt;0.001). Conclusion. In patients with CRF the
   cumulative effect of the drug was registered, with a prolonged recovery time
   from NMB in relation to the patients with normal renal function.</jats:p

Crossref

Srpski arhiv za celokupno lekarstvo

Characteristics of neuromuscular block after administration of rocuronium bromide in patients with end-stage renal failure

Characteristics of neuromuscular block after administration of rocuronium bromide in patients with end-stage renal failure

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