A O'Connor

AR Gennaro

B Krajewska

D Forman

E Jabri

E Yesilada

F Nabati

FJ Lipp

H Azizian

H Dekigai

HL Mobley

K Stingl

K Wolle

M Shokrzadeh

MJ Todd

P Kosikowska

RJ Owen

RK Sindhu

TE Koper

DARU : Journal of Pharmaceutical Sciences

Abstract
          
            Background and purpose of the study
            
              H. pylori infection is an important etiologic impetus usually leading to gastric disease and urease enzyme is the most crucial role is to protect the bacteria in the acidic environment of the stomach. Then urease inhibitors would increase sensitivity of the bacteria in acidic medium.
          
          
            Methods
            137 Iranian traditional medicinal plants were examined against Jack bean urease activity by Berthelot reaction. Each herb was extracted using 50% aqueous methanol. The more effective extracts were further tested and their IC50 values were determined.
          
          
            Results
            37 plants out of the 137 crude extracts revealed strong urease inhibitory activity (more than 70% inhibition against urease activity at 10 mg/ml concentration). Nine of the whole studied plants crude extracts were found as the most effective with IC50 values less than 500 μg/ml including; Rheum ribes, Sambucus ebulus, Pistachia lentiscus, Myrtus communis, Areca catechu, Citrus aurantifolia, Myristica fragrans, Cinnamomum zeylanicum and Nicotiana tabacum.
            
          
          
            Conclusions
            The most potent urease inhibitory was observed for Sambucus ebulus and Rheum ribes extracts with IC50 values of 57 and 92 μg/ml, respectively.
          </jats:sec

Farzaneh Nabati

Faraz Mojab

Mehran Habibi-Rezaei

Kowsar Bagherzadeh

Massoud Amanlou

Behnam Yousefi

Crossref

DARU Journal of Pharmaceutical Sciences

Large scale screening of commonly used Iranian traditional medicinal plants against urease activity

https://darujps.biomedcentral.com/track/pdf/10.1186/2008-2231-20-72?site=darujps.biomedcentral.com

Large scale screening of commonly used Iranian traditional medicinal plants against urease activity

Abstract

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