Adedoyin Thompson

Alice Egerton

Bernd Porr

Florentin Wörgöter

S Cragg

W Schultz

BMC Neuroscience

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BioMed Central
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BMC Neuroscience
Open AccessPoster presentation
How bursting and tonic dopaminergic activity generates LTP and 
LTD
Adedoyin Thompson*1, Bernd Porr1, Alice Egerton2 and Florentin Wörgöter2
Address: 1Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, G12 8LT, UK and 2Bernstein Center for 
Computational Neuroscience, University of Göttingen, Göttingen, Germany
Email: Adedoyin Thompson* - mariat@elec.gla.ac.uk
* Corresponding author    
Dopaminergic activity has commonly been interpreted as
an error signal in which an increased activity codes a pos-
itive error [1] i.e. long term potentiation (LTP), and a
decrease in dopamine concentration codes a negative
error [1] i.e. long term depression (LTD). Recent experi-
mental evidence in the cortical and sub-cortical areas of
the brain [2], propose a different method of generating
LTP or LTD by dopaminergic activity. It is suggested that
LTP or LTD are controlled not by the quantity, but by the
rate of the dopaminergic activity. A model of the sub-cor-
tical nuclei of the limbic system has been shown to imple-
ment a process in which learning and reverse learning of
reward stimulus associations can be achieved. The follow-
ing nuclei are implemented: The nucleus accumbens
(NAcc), with its sub units NAcc shell and NAcc core and
the ventral tegmental area (VTA), which provides a
Dopamine (DA) input to the Nacc. During learning,
bursting dopaminergic activity will dominate and cause
LTP, whereas during reverse learning, tonic dopaminergic
activity will cause LTD. This new coding of dopaminergic
activity has been implemented in the limbic system cir-
cuitry and has successfully been shown to implement a
process in which learning and reverse learning of reward
stimulus associations can be achieved.
References
1. Schultz W, Dayan P, Read Montague P: A neural substrate of pre-
diction and reward.  Science 1997, 275:1593-1599.
2. Cragg S: Meaningful silences: how dopamine listens to the
ACh pause.  Trends Neurosci 2006, 29(3):125-131.
from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007
Toronto, Canada. 7–12 July 2007
Published: 6 July 2007
BMC Neuroscience 2007, 8(Suppl 2):P88 doi:10.1186/1471-2202-8-S2-P88
<supplement> <title> <p>Sixteenth Annual Computational Neuroscience Meeting: CNS*2007</p> </title> <editor>William R Holmes</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http:www.biomedcentral.com/content/pdf/1471-2202-8-S2-full.pdf">here</a></note> <url>http://www.biomedcentral.com/content/pdf/1471-2202-8-S2-info.pdf</url> </supplement>
© 2007 Thompson et al; licensee BioMed Central Ltd. 


How bursting and tonic dopaminergic activity generates LTP and LTD

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How bursting and tonic dopaminergic activity generates LTP and LTD

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