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Clinical dissection of early onset absence epilepsy in children and prognostic implications
Authors
Aglaia Vignoli
Alberto Spalice
+29 more
Alberto Verrotti
B. Dalla Bernardina
Carlo Minetti
Elisabetta Tozzi
Federico Zara
Francesca Beccaria
Francesca Darra
Francesco Nicita
Giuseppe Capovilla
Giuseppe Gobbi
L. Del Gaudio
Lucio Giordano
Maria Paola Canevini
Marianna Pezzella
Maurizio Elia
Michela Sesta
Monica Traverso
Nelia Zamponi
O. N. Behalf Of The Sinp Collaborative Working Group
Pasquale PARISI
Pasquale Striano
Patrizia Accorsi
Piero Pavone
Raffaele Falsaperla
Salvatore Striano
Sergio Agostinelli
Silvia Cappanera
Stella Vari
Vincenzo Belcastro
Publication date
1 January 2013
Publisher
'Wiley'
Doi
Cite
Abstract
Summary Purpose To investigate whether patients with typical absence seizures (TAS) starting in the first 3 years of life, conformed to Panayiotopoulos's definition of childhood absence epilepsy (CAE), show different electroclinical course than those not fulfilling CAE criteria. Methods In this multicenter retrospective study, we choose a fixed duration follow-up of 36 months to examine the electroclinical course of epilepsy in all children with TAS starting before 3 years of age. The probands who fulfilled Panayiotopoulos's criteria for CAE were classified as having pure early onset absence epilepsy (P-EOAE), whereas those who did not as nonpure EOAE (NP-EOAE). In addition, these two groups of patients were further stratified according to the number of antiepileptic drugs taken to obtain initial seizure control (mono-, bi-, and tritherapy). Key Findings Patients with P-EOAE (n = 111) showed earlier initial seizure control (p = 0.030) and better seizure-free survival curve (p = 0.004) than those with NP-EOAE (n = 77). No mutation in SLC2A1 gene or abnormal neuroimaging was observed in P-EOAE. Among patients with NP-EOAE, those receiving tritherapy showed increased risk of structural brain abnormalities (p = 0.001) or SLC2A1 mutations (p = 0.001) but fewer myoclonic features (p = 0.031) and worse seizure-free survival curve (p = 0.047) than those treated with mono- and bitherapy. Children with NP-EOAE had 2.134 the odds of having relapse during the follow-up compare to those with P-EOAE. Significance Children with early onset TAS who did meet Panayiotopoulos's criteria showed a favorable course of epilepsy, whereas patients not fulfilling Panayiotopoulos's criteria showed increased risk of relapse at long-term follow-up. © Wiley Periodicals, Inc. © 2013 International League Against Epilepsy
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Archivio della ricerca- Università di Roma La Sapienza
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oai:iris.uniroma1.it:11573/530...
Last time updated on 12/11/2016
Crossref
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info:doi/10.1111%2Fepi.12341
Last time updated on 01/04/2019