A Tourian

D E Mold

W Y Hung

Five cell cultures of Huntington's-chorea fibroblasts exhibit greater than normal protein and lipid glycosylation when labelled with [U-14C]glucosamine. Oligosaccharide—polypeptide chains from all molecular-weight ranges are labelled differentially on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. This difference in protein glycosylation is not accompanied by any apparent difference in general cellular protein synthesis or by a differential rate of glucosamine uptake or decreased degradation of [14C]glycosylated macromolecules. Additionally [U-14C]glucosamine exclusively labels hexosamines and sialic acid of cellular macromolecules.</jats:p

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Biochemical Journal

Huntington's-chorea fibroblasts. Cellular protein glycosylation

http://www.biochemj.org/content/ppbiochemj/190/3/711.full.pdf

Huntington's-chorea fibroblasts. Cellular protein glycosylation

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