Cheol-Won Lee

Eun-Sang Hwang

Eun-Suk Lee

Ga-Young Choi

Hyun-Bum Kim

Ji-Ho Park

Sang Seong Kim

Seok Lee

Sung-Ok Lee

Tae-Suk Park

Young-Choong Kim

Evidence-Based Complementary and Alternative Medicine

ESP-102, an extract fromAngelica gigas, Saururus chinensis, andSchisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivitiesin vitroandin vivostudies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.</jats:p

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Evidence-based Complementary and Alternative Medicine

ESP-102, a Combined Herbal Extract ofAngelica gigas,Saururus chinensis, andSchisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

http://downloads.hindawi.com/journals/ecam/2016/8793095.pdf

ESP-102, a Combined Herbal Extract of
                    Angelica gigas

ESP-102, a Combined Herbal Extract of Angelica gigas

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