A Madeo

A Schuster

AM Katz

B Sjoli

BD Hoit

BJ Maron

DC Adams

E Abate

FJ Rohlf

FL Bookstein

G Kamalov

G Pacileo

G Pedrizzetti

H Ran

JA Urbano-Moral

K Modesto

LP Isla De

M Alessandrini

M Cikes

M Schwarzl

ML Chuang

N Malpica

O Camara

O Gjesdal

P Piras

R Jasaityte

S Shimoni

V Varano

X Zhang

Y Seo

YT Tan

Scientific Reports

AbstractLeft ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring in systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness about the entire left ventricle or left atrium revolution and on their deficiencies that take place in presence of hypertrophic cardiomyopathy. However, surprisingly, the concomitant function of the two left heart chambers has not been analyzed for their geometrical/mechanical relationship. For the first time we study here, by acquiring left ventricle and left atrial geometries on the same heartbeat, the trajectory attributes of the entire left heart treated as a whole shape and the shape covariation of its two subunits. We contrasted healthy subjects with patients affected by hypertrophic cardiomyopathy. We found impaired left heart trajectory mainly in terms of orientation and size. More importantly, we found profound differences in the direction of morphological covariation of left ventricle and left atrium. These findings open to new perspectives in pathophysiological evaluation of different diseases by allowing the appreciation of concomitant functioning of both left heart whole geometry and of its two chambers.</jats:p

Paolo Piras

Concetta Torromeo

Antonietta Evangelista

Stefano Gabriele

Giuseppe Esposito

Paola Nardinocchi

Luciano Teresi

Andrea Madeo

Michele Schiariti

Valerio Varano

Paolo Emilio Puddu

Crossref

Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy

Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy

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