A Moghaddam

A Rauch

Abdallah Al-Mdani

Ahmed Al-Qahtani

Ahmed Helmy

Ali Albenmousa

Ayman A. Abdo

CM Lange

D Ge

DL Thomas

Faisal M. Sanai

Faleh Z. Al Faleh

Hamad I. Al-Ashgar

JJ McCarthy

Khalid Alswat

MA Khattab

Mashael Al-Anazi

ML Yu

Mohammed N. Al-Ahdal

NE Pagliaccetti

Nisreen Khalaf

PJ Clark

S Nicola De

S Zeuzem

Safiyya M. Ali

Saira S. Khalid

SJ Hadziyannis

T Asselah

TM Scherzer

V Suppiah

W Hou

Waleed Al-hamoudi

Y Tanaka

Abstract
          
            Background
            Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited.
          
          
            Aim
            We analyzed the association of IL28B SNPs (hematological, biochemical, virological, and pathological factors) with SVR in the HCV-G4 monoinfected cohort of patients.
          
          
            Patients and methods
            One hundred twenty-nine treatment-naïve HCV-G4 patients undergoing treatment were recruited from three tertiary care centers in Saudi Arabia. Five IL28B SNPs (rs12979860, rs12980275, rs8105790, rs8099917, and rs72486680) were identified by polymerase chain reaction and DNA sequencing. SVR was statistically correlated with various clinical, histopathological, virological, and genetic parameters.
          
          
            Results
            SVR was significantly associated with the CC and AA alleles of rs12979860 (p = 0.008) and rs12980275 (p = 0.004), respectively. Moreover, albumin levels (p = 0.002) and platelet count (p = 0.039) showed significant differences in the SVR and No SVR groups. On multivariate analysis, the CC allele of rs12979860 (OR, 2.89; 95 % CI 1.6–6.2, p = 0.006) and albumin levels (OR, 1.2; 95 % CI 1.1–1.4, p = 0.001) independently predicted SVR.
          
          
            Conclusions
            IL28B polymorphism (CC allele of rs12979860) predicts the sustained response to antiviral therapy in HCV-G4.
          </jats:sec

Crossref

Hepatology International

IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection

https://link.springer.com/content/pdf/10.1007%2Fs12072-013-9421-8.pdf

IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection

Abstract

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