F Stirpe

H Franz

L J Onyon

P Ziska

R F Legg

1. The haemagglutinating and toxic lectin from Viscum album L. (mistletoe) inhibits protein synthesis in a lysate of rabbit reticulocytes, with an ID50 (concentration giving 50% inhibition) of 2.6 microgram/ml. This effect is enhanced (ID50 0.21 microgram/ml) if the lectin is reduced with 2-mercaptoethanol. 2. The lectin inhibits protein synthesis also in BL8L cells in culture. Inhibition occurs after a lag time of 3 h. The ID50 is 7 ng/ml, and increases after reduction of the lectin. 3. This and the gross lesions observed in rats poisoned with V. album lectin indicate this is a toxin very similar to ricin.</jats:p

Crossref

Biochemical Journal

Inhibition of protein synthesis by a toxic lectin from <i>Viscum album</i> L. (mistletoe)

http://www.biochemj.org/content/ppbiochemj/190/3/843.full.pdf

Inhibition of protein synthesis by a toxic lectin from Viscum album L. (mistletoe)

Abstract

Similar works

Full text

Available Versions

Crossref