Synthesis of Triazole-Functionalized Tetrahydroindazolones by 1,3-dipolar Cycloadditions between Azides and Alkynes

Abstract

7-Azido-tetrahydroindazolones undergo efficient copper-catalyzed Huisgen 1,3-dipolar cycloaddition reactions with various alkynes leading to a straightforward synthesis of triazole-functionalized tetrahydroindazolones. The latter are interesting molecular platforms in terms of medicinal chemistry