Paper presented at the 7th European Conference in Case-Based Reasoning, Madrid, Spain.NutriGenomics is the bioscience that links the way nutrients and
other dietary components shape genetic activity. It builds on the success of
Human Genome Project by applying systems biology methods to explain how
the molecular components of food, supplements and pharmaceuticals dynamically
influence and shape the activity of genomic subsystems, which in turn define
how a person can stay healthy or become ill. Applying NutriGenomics
knowledge is done through Directive Genomics, which develops purposeful
dietary strategies that influence gene expression at the individual level with the
goal of better genetic function and health. This paper proposes a case-based
framework for leveraging nutrigenomics knowledge and Directive Genomics
applications. The unique features of the proposed system include a selfmaintained
distributed case base structure and a CBR-based nutrition counseling
module that can learn, adapt, and maintain its case base via the integrated
distributed case bases as well as external resources
