Dynamic hi-resolution horizontal microscope for monitoring and manipulating real-time tissue assembly

Abstract

Poster presented at Biomedical Technology Showcase 2006, Philadelphia, PA. Retrieved 18 Aug 2006 from http://www.biomed.drexel.edu/new04/Content/Biomed_Tech_Showcase/Poster_Presentations/Lelkes_4.pdf.There is an un-met clinical and technological need in regenerative medicine and tissue engineering for developing a non-invasive technique for monitoring and manipulating tissue assembly. Our goal is to create an integrated hardware/ software system to automatically diagnose, monitor, and control tissue growth in dynamic bioreactors in real-time. For this we propose to engineer and test a versatile, hi-resolution horizontal microscope that can intelligently aid in the on-line optimization of tissue growth parameters within a bioreactor. Having developed a functional prototype, we succeeded in compacting and significantly reducing the costs for the 2nd generation system, which now needs further validation

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