Research Journal of Applied Sciences, Engineering and Technology
Abstract
The aim of the present study was to investigate the effects of pre- and post- administration of garlic
extract on serum glucose and some biochemical parameters in alloxan-induced diabetic rats to show the
preventive and ameliorating effects in alloxan induced-diabetic rats. Rats were divided into 4 groups; normal
control rats, diabetic control rats, diabetic rats post-treated with garlic extract and rats pre-treated with garlic
extract before induction. Garlic extract was administered orally for 2 weeks to post-treated rats and 3 weeks
to pre-treated rats and they were compared with the normal and diabetic groups, respectively. Serum glucose
was reduced significantly in both post-treated and pre-treated groups. The post-treatment with garlic extract
reduced serum cholesterol, but pre-treatment with garlic extract produced significant change compare to the
diabetic control. The serum creatinine and urea levels were significantly reduced in post-treated group and pretreated
group compare to the diabetic control group. It is concluded that the consumption of garlic produced
a significant hypoglycaemic and hypolipidemic effects in diabetic rats and also, garlic is capable of protecting
the liver and the kidney functions in alloxan-induced diabetic rats as shown in the activities of serum enzymes
and other biochemical parameters examined
