Gadolinium: Een uitlokkende factor van nefrogene systemische fibrose?

Abstract

A 69-year-old female haemodialysis patient developed a sclerotic skin on the legs with pruritus. Two weeks before she underwent MRI scanning with a gadolinium containing contrast agent. She was diagnosed with nephrogenic systemic fibrosis (NSF). NSF is a progressive disease with significant morbidity and mortality. It is most likely caused by gadolinium containing contrast agents used in imaging studies (MRI/MRA). The disease occurs almost exclusively in patients with strongly diminished renal function, in whom the contrast agent is not eliminated fast enough and gadolinium is deposited in the skin