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Synthesis and Self-Assembly of Well-Defined Block Copolypeptides via Controlled NCA Polymerization
Authors
A Aggeli
A Aggeli
+111 more
A Sulistio
AA Goodwin
AH Zisch
AJ Rhodes
AP Nowak
AP Nowak
AR Rodriguez
B Song
BJ Sparks
C Branden
C Chen
C Holt
C-Y Yang
D Thunig
DE Discher
DL Pickel
E Bellomo
E Katchalski
EP Holowka
EP Holowka
EP Holowka
F Cardinaux
F Uralil
FPJT Rutjes
G Kwon
GD Fasman
GJM Habraken
GJM Habraken
GS Kwon
H Cao
H Fischer
H Iatrou
H Lu
H Lu
H Lu
H Sekiguchi
H Sekiguchi
HE Auer
HR Kricheldorf
J Cheng
J Gaspard
J Huang
J Hwang
J Rodriguez-Hernandez
J Sun
J-F Lutz
J-K Lai
JA Hanson
JA Hanson
JA Hanson
JC Howard
JH Waite
JN Cha
JP Collman
JR Kramer
JR Kramer
JR Kramer
JR Kramer
JW Nah
KE Schaefer
KR Brzezinska
KY Lee
L Pakstis
L Richert
L Xia
L-TT Nguyen
LF Zhang
M Meyer
M Mondeshki
M Sela
M Wilhelm
M Yu
MI Gibson
MP Lutolf
NA Peppas
O Webster
O Webster
P Alexandridis
P Witte
R Graf
RB Woodward
RE Epand
RT Ingwall
S Kubota
S Zhang
SA Curtin
SE Ostroy
SW Seidel
T Aliferis
T Kidchob
T Tanaka
TJ Deming
TJ Deming
TJ Deming
TJ Deming
TJ Deming
TJ Deming
TJ Deming
TJ Deming
U-J Choe
VP Torchilin
VZ Sun
VZ Sun
W Vayaboury
W Zhuang
X Fu
Y Liu
Y-L Peng
Y-Y Hu
YI Jeong
Z Li
Publication date
1 January 2013
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
This article summarizes advances in the synthesis of well-defined polypeptides and block copolypeptides. Traditional methods used to polymerize α-amino acid-N-carboxyanhydrides (NCAs) are described, and limitations in the utility of these systems for the preparation of polypeptides are discussed. Improved initiators and methods that allow polypeptide synthesis with good control over chain length, chain length distribution, and chain-end functionality are also discussed. Using these methods, block and random copolypeptides of controlled dimensions (including molecular weight, sequence, composition, and molecular weight distribution) can now be prepared. The ability of well-defined block copolypeptides to assemble into supramolecular copolypeptide micelles, copolypeptide vesicles, and copolypeptide hydrogels is described. Many of these assemblies have been found to possess unique properties that are derived from the amino acid building blocks and ordered conformations of the polypeptide segments. © Springer-Verlag Berlin Heidelberg 2013
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info:doi/10.1007%2F12_2013_234
Last time updated on 27/03/2019
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eScholarship - University of California
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Last time updated on 25/12/2021