Penicillin was isolated from Penicillium notatum by Fleming in 1928 and introduced into clinical medicine in 1941 by Florey, Chain, and associates (Fleming, 1929; Chain et al., 1940; Abraham, 1980). The history of penicillin is recorded in a number of monographs (Hare, 1970; Bickel, 1972; Bud, 2007)