Hadrup, Sine Reker

Jakobsen, Søren Nyboe

Rafa, Vibeke Mindahl

The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise antigens, such as peptide-MHC (pMHC) class I molecules, and specific combinations of cytokines and co-stimulatory molecules to allow effective expansion and functional stimulation of specific T cells.<br/

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Antigen presenting scaffolds for immune-cell manipulation

http://orbit.dtu.dk/ws/files/160135751/WO2018115146A1.pdf

Antigen presenting scaffolds for immune-cell manipulation

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