PDIA3 protein is a prominent member of the PDI family that has attracted a significant attention by the research community. It is also becoming increasingly evident that PDIA3 could be a pharmacological target in different pathological conditions, though the mechanisms in which it is involved are not completely understood. For this reason, my PhD project puts the spotlight on the PDIA3 involvement in disease processes, focusing on Alzheimer disease and platelet aggregation, and then characterizing its new features and roles in the development of the aforementioned diseases. At present, no selective compounds are known to modulate the PDIA3 biological functions. The discovery of specific PDIA3 interactors could be used in repressing or stimulating PDIA3 in biological model, thus providing useful information on PDIA3 functions
