Summary Points\u2022The treatment gap for mental, neurological, and substance use (MNS) disorders is more than 75% in many low- and middle-income countries.\u2022In order to reduce the gap, the World Health Organization (WHO) has developed a model intervention guide within its Mental Health Gap Action Programme (mhGAP).\u2022The model intervention guide provides evidence-based recommendations developed with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.\u2022This article presents the management recommendations for MNS disorders, with a link to the World Health Organization website where all the background material may be accessed.\u2022To our knowledge, this is a first exercise involving such an extensive and systematic evaluation of evidence in this area
