Audenaert, Kurt

Baeken, Chris

Bosmans, Tim

De Spiegeleer, Bart

Dockx, Robrecht

Peremans, Kathelijne

Polis, Ingeborgh

Saunders, Jimmy

Vlerick, Lise

English

Ghent University Academic Bibliography

99MTC-HMPAO SPECT AFTER SINGLE AND REPEATED SUBANAESTHETIC KETAMINE IN HEALTHY DOGS   Lise Vlerick1,*, Kathelijne Peremans2, Robrecht Dockx3, Kurt Audenaert3, Chris Baeken3, Bart De Spiegeleer4,  Jimmy Saunders2, Tim Bosmans1, Ingeborgh Polis1  Abstract  Ketamine has been proven to possess rapid antidepressant effects. The mechanisms responsible for ketamine’s antidepressant effects remain unclear, but a possible explanation could be that ketamine interacts with regional cerebral blood flow (rCBF).  Therefore, rCBF was evaluated after single and repeated ketamine infusion in dogs. The study involved three groups of dogs with one group receiving saline, one group receiving ketamine at a dose of 0.5 mg kg-1, and one group receiving ketamine at 2 mg kg-1 (n = 24). Each animal received in total five ketamine or saline infusions, with one week interval. Single Photon Emission Computed Tomography (SPECT) scans with 99mTc-hexamethylpropylene amine oxime were performed before the start of the infusions and 24 hours after the first (single) and last (repeated) infusion. In all groups, the total dose of ketamine or saline was administered intravenously over 40-minutes. A one-way repeated measure ANOVA was set up to assess perfusion index for each ketamine dose for the left frontal cortex (alpha = 0,05). The remaining 11 brain regions were post hoc assessed. Perfusion index was significantly increased in the left frontal cortex and in the thalamus 24 hours after single (1.15 ± 0.03 and 1.18 ± 0.04 respectively) and repeated (1.15 ± 0.02 and 1.19 ± 0.05 respectively) ketamine compared to baseline (1.11 ± 0.02 and 1.15 ± 0.05 respectively) in the 2 mg kg-1 group.  This dog model shows that subanaesthetic ketamine can increase neuronal perfusion and therefore alter neuronal function in brain regions involved in psychiatric disorders.  Ethical statement  This study was approved by the local Ethical Committee of the Faculty of Veterinary Medicine, Ghent University (EC 2015_130 and EC 2016_60) and all procedures were performed according to good animal practice. 

99mTc-HMPAO SPECT after single and repeated subanaesthetic ketamine in healthy dogs

https://biblio.ugent.be/publication/8587895/file/8587979.pdf

99mTc-HMPAO SPECT after single and repeated subanaesthetic ketamine in healthy dogs

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Ghent University Academic Bibliography