My Bachelor thesis focuses on life quality evaluation and nutritional status development in patients on a home parenteral nutrition (HPN). Theoretical part focuses on general information about patient examination after their arrival in a hospital. It further focuses on indication, division, composition and complications of parenteral nutrition and it gives a brief summary of basic knowledge about parenteral nutrition applied in home environment. HPN is most often recommended in patients with short bowel syndrom, ileus or some oncological diseases. The main expected benefit of HPN is an option for the patient to persist at home surrounded by family as opposed to being in a hospital. Even though HPN still comes with many complications, these patients still have a chance to live a relatively normal life. Two goals were set to evaluate the practical part of the thesis. First goal is to assesses the quality of life of patients on HPN and to determine whether the quality of life is changed and if so then how. Second goal is to describe the change of nutritional status in patients on home parenteral nutrition. These goals were achieved by using research questions focused on determining patient's feelings, health complications, ability to take part in physical activity and to integrate back into their work..